Metformin-Induced Lactic Acidosis: A Question of Time

Metformin is an oral antidiabetic largely prescribed in the treatment of type II diabetes. Overdose is associated with life-threatening lactic acidosis. We report the case of the highest metformin concentration ever described secondary to a voluntary suicidal intake. The patient developed a severe l...

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Detalles Bibliográficos
Autores principales: Bellefroid, Céline, Goffin, Pierre, Guntz, Julien, Deville, Marine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596499/
https://www.ncbi.nlm.nih.gov/pubmed/33145113
http://dx.doi.org/10.1155/2020/6962591
Descripción
Sumario:Metformin is an oral antidiabetic largely prescribed in the treatment of type II diabetes. Overdose is associated with life-threatening lactic acidosis. We report the case of the highest metformin concentration ever described secondary to a voluntary suicidal intake. The patient developed a severe lactic acidosis and hemodynamic shock successfully treated with high-flow hemofiltration. Time to start extrarenal epuration is capital to avoid poor evolution.

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