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Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibili...

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Autores principales: Cao, Yuqing, Wang, Xiaoyu, Jin, Tianqiang, Tian, Yu, Dai, Chaoliu, Widarma, Crystal, Song, Rui, Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596531/
https://www.ncbi.nlm.nih.gov/pubmed/33122640
http://dx.doi.org/10.1038/s41392-020-00348-8
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author Cao, Yuqing
Wang, Xiaoyu
Jin, Tianqiang
Tian, Yu
Dai, Chaoliu
Widarma, Crystal
Song, Rui
Xu, Feng
author_facet Cao, Yuqing
Wang, Xiaoyu
Jin, Tianqiang
Tian, Yu
Dai, Chaoliu
Widarma, Crystal
Song, Rui
Xu, Feng
author_sort Cao, Yuqing
collection PubMed
description Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex. The discovery of the NK’s potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers. NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy. The effector role of these cells is reliant on the balance of inhibitory and activating signals. Understanding the role of various immune checkpoint molecules in the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is particularly important in cancer immunotherapy studies and clinical implementation. Emerging immune checkpoint receptors and molecules have been found to mediate NK cell dysfunction in the tumor microenvironment; this has brought up the need to explore further additional NK cell-related immune checkpoints that may be exploited to enhance the immune response to refractory cancers. Accordingly, this review will focus on the recent findings concerning the roles of immune checkpoint molecules and receptors in the regulation of NK cell function, as well as their potential application in tumor immunotherapy.
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spelling pubmed-75965312020-11-02 Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy Cao, Yuqing Wang, Xiaoyu Jin, Tianqiang Tian, Yu Dai, Chaoliu Widarma, Crystal Song, Rui Xu, Feng Signal Transduct Target Ther Review Article Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex. The discovery of the NK’s potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers. NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy. The effector role of these cells is reliant on the balance of inhibitory and activating signals. Understanding the role of various immune checkpoint molecules in the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is particularly important in cancer immunotherapy studies and clinical implementation. Emerging immune checkpoint receptors and molecules have been found to mediate NK cell dysfunction in the tumor microenvironment; this has brought up the need to explore further additional NK cell-related immune checkpoints that may be exploited to enhance the immune response to refractory cancers. Accordingly, this review will focus on the recent findings concerning the roles of immune checkpoint molecules and receptors in the regulation of NK cell function, as well as their potential application in tumor immunotherapy. Nature Publishing Group UK 2020-10-29 /pmc/articles/PMC7596531/ /pubmed/33122640 http://dx.doi.org/10.1038/s41392-020-00348-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Cao, Yuqing
Wang, Xiaoyu
Jin, Tianqiang
Tian, Yu
Dai, Chaoliu
Widarma, Crystal
Song, Rui
Xu, Feng
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title_full Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title_fullStr Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title_full_unstemmed Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title_short Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
title_sort immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596531/
https://www.ncbi.nlm.nih.gov/pubmed/33122640
http://dx.doi.org/10.1038/s41392-020-00348-8
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