GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

BACKGROUND: Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia compromises the clearance of invading pathogens by impairin...

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Detalles Bibliográficos
Autores principales: Sitapara, Ravikumar A., Gauthier, Alex G., Patel, Vivek S., Lin, Mosi, Zur, Michelle, Ashby, Charles R., Mantell, Lin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596622/
https://www.ncbi.nlm.nih.gov/pubmed/33126860
http://dx.doi.org/10.1186/s10020-020-00224-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596622/
https://www.ncbi.nlm.nih.gov/pubmed/33126860
http://dx.doi.org/10.1186/s10020-020-00224-9

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