Cargando…
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression, in which AKT activation plays an important role. β-Catenin de...
Autores principales: | Du, Linyong, Lee, Jong-Ho, Jiang, Hongfei, Wang, Chengde, Wang, Silu, Zheng, Zhihong, Shao, Fei, Xu, Daqian, Xia, Yan, Li, Jing, Zheng, Yanhua, Qian, Xu, Li, Xinjian, Kim, Hyung-Ryong, Xing, Dongming, Liu, Pengyuan, Lu, Zhimin, Lyu, Jianxin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596815/ https://www.ncbi.nlm.nih.gov/pubmed/32860047 http://dx.doi.org/10.1084/jem.20191115 |
Ejemplares similares
-
EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion
por: Du, Linyong, et al.
Publicado: (2023) -
The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62
por: Xu, Daqian, et al.
Publicado: (2019) -
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
por: Ricklefs, Franz L., et al.
Publicado: (2018) -
Immunological Evasion in Glioblastoma
por: Magaña-Maldonado, Roxana, et al.
Publicado: (2016) -
A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis
por: Jiang, Hongfei, et al.
Publicado: (2020)