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Imaging resident and recruited macrophage contribution to Wallerian degeneration

Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be in...

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Autores principales: Boissonnas, Alexandre, Louboutin, Floriane, Laviron, Marie, Loyher, Pierre-Louis, Reboussin, Elodie, Barthelemy, Sandrine, Réaux-Le Goazigo, Annabelle, Lobsiger, Christian S., Combadière, Béhazine, Mélik Parsadaniantz, Stéphane, Combadière, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596821/
https://www.ncbi.nlm.nih.gov/pubmed/32648893
http://dx.doi.org/10.1084/jem.20200471
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author Boissonnas, Alexandre
Louboutin, Floriane
Laviron, Marie
Loyher, Pierre-Louis
Reboussin, Elodie
Barthelemy, Sandrine
Réaux-Le Goazigo, Annabelle
Lobsiger, Christian S.
Combadière, Béhazine
Mélik Parsadaniantz, Stéphane
Combadière, Christophe
author_facet Boissonnas, Alexandre
Louboutin, Floriane
Laviron, Marie
Loyher, Pierre-Louis
Reboussin, Elodie
Barthelemy, Sandrine
Réaux-Le Goazigo, Annabelle
Lobsiger, Christian S.
Combadière, Béhazine
Mélik Parsadaniantz, Stéphane
Combadière, Christophe
author_sort Boissonnas, Alexandre
collection PubMed
description Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be involved, but whether these two subsets exert distinct functions is unknown. Combining MP-designed fluorescent reporter mice and coherent anti–Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs being responsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regrowth. This work provides clues to tackle selectively cellular processes involved in neurodegenerative diseases.
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spelling pubmed-75968212021-05-02 Imaging resident and recruited macrophage contribution to Wallerian degeneration Boissonnas, Alexandre Louboutin, Floriane Laviron, Marie Loyher, Pierre-Louis Reboussin, Elodie Barthelemy, Sandrine Réaux-Le Goazigo, Annabelle Lobsiger, Christian S. Combadière, Béhazine Mélik Parsadaniantz, Stéphane Combadière, Christophe J Exp Med Brief Definitive Report Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be involved, but whether these two subsets exert distinct functions is unknown. Combining MP-designed fluorescent reporter mice and coherent anti–Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs being responsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regrowth. This work provides clues to tackle selectively cellular processes involved in neurodegenerative diseases. Rockefeller University Press 2020-07-10 /pmc/articles/PMC7596821/ /pubmed/32648893 http://dx.doi.org/10.1084/jem.20200471 Text en © 2020 Boissonnas et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Boissonnas, Alexandre
Louboutin, Floriane
Laviron, Marie
Loyher, Pierre-Louis
Reboussin, Elodie
Barthelemy, Sandrine
Réaux-Le Goazigo, Annabelle
Lobsiger, Christian S.
Combadière, Béhazine
Mélik Parsadaniantz, Stéphane
Combadière, Christophe
Imaging resident and recruited macrophage contribution to Wallerian degeneration
title Imaging resident and recruited macrophage contribution to Wallerian degeneration
title_full Imaging resident and recruited macrophage contribution to Wallerian degeneration
title_fullStr Imaging resident and recruited macrophage contribution to Wallerian degeneration
title_full_unstemmed Imaging resident and recruited macrophage contribution to Wallerian degeneration
title_short Imaging resident and recruited macrophage contribution to Wallerian degeneration
title_sort imaging resident and recruited macrophage contribution to wallerian degeneration
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596821/
https://www.ncbi.nlm.nih.gov/pubmed/32648893
http://dx.doi.org/10.1084/jem.20200471
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