β-Catenin regulates tumor-derived PD-L1

In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model...

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Detalles Bibliográficos
Autores principales: Han, Chuanhui, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596827/
https://www.ncbi.nlm.nih.gov/pubmed/32860048
http://dx.doi.org/10.1084/jem.20200684
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author Han, Chuanhui
Fu, Yang-Xin
author_facet Han, Chuanhui
Fu, Yang-Xin
author_sort Han, Chuanhui
collection PubMed
description In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model.
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spelling pubmed-75968272021-05-02 β-Catenin regulates tumor-derived PD-L1 Han, Chuanhui Fu, Yang-Xin J Exp Med Insights In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model. Rockefeller University Press 2020-08-27 /pmc/articles/PMC7596827/ /pubmed/32860048 http://dx.doi.org/10.1084/jem.20200684 Text en © 2020 Han and Fu http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Han, Chuanhui
Fu, Yang-Xin
β-Catenin regulates tumor-derived PD-L1
title β-Catenin regulates tumor-derived PD-L1
title_full β-Catenin regulates tumor-derived PD-L1
title_fullStr β-Catenin regulates tumor-derived PD-L1
title_full_unstemmed β-Catenin regulates tumor-derived PD-L1
title_short β-Catenin regulates tumor-derived PD-L1
title_sort β-catenin regulates tumor-derived pd-l1
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596827/
https://www.ncbi.nlm.nih.gov/pubmed/32860048
http://dx.doi.org/10.1084/jem.20200684
work_keys_str_mv AT hanchuanhui bcateninregulatestumorderivedpdl1
AT fuyangxin bcateninregulatestumorderivedpdl1

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