Cargando…

Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis

A 47-year-old male with macroglossia presented with dyspnea on effort and chest pain at rest. Cardiac MRI revealed diffuse global subendocardial late gadolinium enhancement below the left ventricular endocardium and a dark blood pool of intracardiac contrast medium. Tongue biopsy revealed amyloid de...

Descripción completa

Detalles Bibliográficos
Autores principales: Sekiguchi, Yasunobu, Wakabayashi, Mutsumi, Iizuka, Hiroko, Takizawa, Haruko, Sugimoto, Keiji, Sakajiri, Sakura, Inano, Tadaaki, Fukuda, Yasutaka, Hamano, Yasuharu, Tomita, Shigeki, Izumi, Hiroshi, Isogai, Hiroyuki, Okubo, Mitsuo, Nakamura, Noriko, Sawada, Tomohiro, Matsumoto, Kimihiro, Noguchi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596909/
https://www.ncbi.nlm.nih.gov/pubmed/32779613
http://dx.doi.org/10.3960/jslrt.19040
_version_ 1783602212443783168
author Sekiguchi, Yasunobu
Wakabayashi, Mutsumi
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Isogai, Hiroyuki
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Matsumoto, Kimihiro
Noguchi, Masaaki
author_facet Sekiguchi, Yasunobu
Wakabayashi, Mutsumi
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Isogai, Hiroyuki
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Matsumoto, Kimihiro
Noguchi, Masaaki
author_sort Sekiguchi, Yasunobu
collection PubMed
description A 47-year-old male with macroglossia presented with dyspnea on effort and chest pain at rest. Cardiac MRI revealed diffuse global subendocardial late gadolinium enhancement below the left ventricular endocardium and a dark blood pool of intracardiac contrast medium. Tongue biopsy revealed amyloid deposition, which was limited in the myocardium. He was diagnosed with primary light chain amyloidosis. His condition was stage I according to the Mayo Clinic staging system. He underwent autologous peripheral blood stem cell transplantation. On Day 10, he developed chest pain and died suddenly on Day 11. Postmortem examination revealed amyloid deposition throughout the heart.
format Online
Article
Text
id pubmed-7596909
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher JSLRT
record_format MEDLINE/PubMed
spelling pubmed-75969092020-11-03 Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis Sekiguchi, Yasunobu Wakabayashi, Mutsumi Iizuka, Hiroko Takizawa, Haruko Sugimoto, Keiji Sakajiri, Sakura Inano, Tadaaki Fukuda, Yasutaka Hamano, Yasuharu Tomita, Shigeki Izumi, Hiroshi Isogai, Hiroyuki Okubo, Mitsuo Nakamura, Noriko Sawada, Tomohiro Matsumoto, Kimihiro Noguchi, Masaaki J Clin Exp Hematop Case Report A 47-year-old male with macroglossia presented with dyspnea on effort and chest pain at rest. Cardiac MRI revealed diffuse global subendocardial late gadolinium enhancement below the left ventricular endocardium and a dark blood pool of intracardiac contrast medium. Tongue biopsy revealed amyloid deposition, which was limited in the myocardium. He was diagnosed with primary light chain amyloidosis. His condition was stage I according to the Mayo Clinic staging system. He underwent autologous peripheral blood stem cell transplantation. On Day 10, he developed chest pain and died suddenly on Day 11. Postmortem examination revealed amyloid deposition throughout the heart. JSLRT 2020-08-08 /pmc/articles/PMC7596909/ /pubmed/32779613 http://dx.doi.org/10.3960/jslrt.19040 Text en © 2020 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Sekiguchi, Yasunobu
Wakabayashi, Mutsumi
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Isogai, Hiroyuki
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Matsumoto, Kimihiro
Noguchi, Masaaki
Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title_full Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title_fullStr Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title_full_unstemmed Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title_short Significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
title_sort significant role of magnetic resonance imaging for the diagnosis and evaluation of cardiac amyloidosis in primary light chain amyloidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596909/
https://www.ncbi.nlm.nih.gov/pubmed/32779613
http://dx.doi.org/10.3960/jslrt.19040
work_keys_str_mv AT sekiguchiyasunobu significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT wakabayashimutsumi significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT iizukahiroko significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT takizawaharuko significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT sugimotokeiji significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT sakajirisakura significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT inanotadaaki significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT fukudayasutaka significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT hamanoyasuharu significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT tomitashigeki significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT izumihiroshi significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT isogaihiroyuki significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT okubomitsuo significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT nakamuranoriko significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT sawadatomohiro significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT matsumotokimihiro significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis
AT noguchimasaaki significantroleofmagneticresonanceimagingforthediagnosisandevaluationofcardiacamyloidosisinprimarylightchainamyloidosis