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An autopsy case of acute myocarditis with unique lymph node findings characterized by the proliferation of reactive plasmablasts

We report an autopsy case of acute myocarditis, in which the mediastinal lymph nodes exhibited unique findings. A 15-year-old Japanese boy was diagnosed with the secondary onset of acute myocarditis. No viruses were identified. Autopsy confirmed acute lymphocytic myocarditis. Lymphadenopathy was obs...

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Detalles Bibliográficos
Autores principales: Ohtani, Haruo, Nozaki, Yoshihiro, Murakami, Takashi, Lin, Lisheng, Shiono, Junko, Miyazawa, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596914/
https://www.ncbi.nlm.nih.gov/pubmed/32981914
http://dx.doi.org/10.3960/jslrt.20023
Descripción
Sumario:We report an autopsy case of acute myocarditis, in which the mediastinal lymph nodes exhibited unique findings. A 15-year-old Japanese boy was diagnosed with the secondary onset of acute myocarditis. No viruses were identified. Autopsy confirmed acute lymphocytic myocarditis. Lymphadenopathy was observed, especially in pulmonary hilar/mediastinal areas. Microscopically, interfollicular areas were uniformly filled with medium-sized, round cells that resembled lymphocytes. They were immunohistochemically CD3(-) CD5(-) CD19(+) CD20(-) CD79a(-) Pax-5(-) CD138(+) MUM1(+) LMP1(-) EBNA2(-) cytoplasmic IgG(+) IgA(-) and IgM(-). No monotypia was observed for kappa and lambda light chains, and multiplex polymerase chain reaction analyses of immunoglobulin heavy chain variable region diversity demonstrated oligoclonal peaks, suggesting reactive change. IgG(+) or VS38c(+) cells frequently co-expressed Ki-67 (up to 80%). We considered these cells abundantly present in lymph nodes to be reactive plasmablasts because they were early plasma cells with proliferative activity.