A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies. METHODS: We used an approach based on the retention in tu...

Descripción completa

Detalles Bibliográficos
Autores principales: Lo Riso, Pietro, Villa, Carlo Emanuele, Gasparoni, Gilles, Vingiani, Andrea, Luongo, Raffaele, Manfredi, Anna, Jungmann, Annemarie, Bertolotti, Alessia, Borgo, Francesca, Garbi, Annalisa, Lupia, Michela, Laise, Pasquale, Das, Vivek, Pruneri, Giancarlo, Viale, Giuseppe, Colombo, Nicoletta, Manzo, Teresa, Nezi, Luigi, Cavallaro, Ugo, Cacchiarelli, Davide, Walter, Jörn, Testa, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597028/
https://www.ncbi.nlm.nih.gov/pubmed/33121525
http://dx.doi.org/10.1186/s13073-020-00786-7

Ejemplares similares

Ejemplares similares