Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less...

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Autores principales: Delemarre, Tim, De Ruyck, Natalie, Holtappels, Gabriele, Bachert, Claus, Gevaert, Elien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597062/
https://www.ncbi.nlm.nih.gov/pubmed/33292477
http://dx.doi.org/10.1186/s13601-020-00348-5
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author Delemarre, Tim
De Ruyck, Natalie
Holtappels, Gabriele
Bachert, Claus
Gevaert, Elien
author_facet Delemarre, Tim
De Ruyck, Natalie
Holtappels, Gabriele
Bachert, Claus
Gevaert, Elien
author_sort Delemarre, Tim
collection PubMed
description Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examined S. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated by S. aureus and its enterotoxin B in vitro. These findings underline the contribution of S. aureus and define IL-9 as another relevant cytokine in type 2 CRSwNP.
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spelling pubmed-75970622020-11-02 Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus Delemarre, Tim De Ruyck, Natalie Holtappels, Gabriele Bachert, Claus Gevaert, Elien Clin Transl Allergy Letter to the Editor Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examined S. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated by S. aureus and its enterotoxin B in vitro. These findings underline the contribution of S. aureus and define IL-9 as another relevant cytokine in type 2 CRSwNP. BioMed Central 2020-10-19 /pmc/articles/PMC7597062/ /pubmed/33292477 http://dx.doi.org/10.1186/s13601-020-00348-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Delemarre, Tim
De Ruyck, Natalie
Holtappels, Gabriele
Bachert, Claus
Gevaert, Elien
Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title_full Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title_fullStr Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title_full_unstemmed Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title_short Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
title_sort unravelling the expression of interleukin-9 in chronic rhinosinusitis: a possible role for staphylococcus aureus
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597062/
https://www.ncbi.nlm.nih.gov/pubmed/33292477
http://dx.doi.org/10.1186/s13601-020-00348-5
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