Cargando…

Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens

Feed additives can be alternatives to antibiotics for routinely encountered pathogens in the poultry production. The objective of this study was to understand effects of organic acid mixture on growth parameters and Salmonella Typhimurium (ST) colonization in broilers. Organic acid mixture is a feed...

Descripción completa

Detalles Bibliográficos
Autores principales: Adhikari, Pratima, Yadav, Sudhir, Cosby, Douglas E., Cox, Nelson A., Jendza, Joshua A., Kim, Woo Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597380/
https://www.ncbi.nlm.nih.gov/pubmed/32359600
http://dx.doi.org/10.1016/j.psj.2019.12.037
_version_ 1783602333884612608
author Adhikari, Pratima
Yadav, Sudhir
Cosby, Douglas E.
Cox, Nelson A.
Jendza, Joshua A.
Kim, Woo Kyun
author_facet Adhikari, Pratima
Yadav, Sudhir
Cosby, Douglas E.
Cox, Nelson A.
Jendza, Joshua A.
Kim, Woo Kyun
author_sort Adhikari, Pratima
collection PubMed
description Feed additives can be alternatives to antibiotics for routinely encountered pathogens in the poultry production. The objective of this study was to understand effects of organic acid mixture on growth parameters and Salmonella Typhimurium (ST) colonization in broilers. Organic acid mixture is a feed-grade buffered formic acid and sodium formate mixture (Amasil NA). A total of 800 1-day-old Cobb500 males were fed one of the five dietary treatments: a negative control diet without ST challenge (NC), positive control diet with ST challenge (PC), 0.3% organic acid mixture with ST, 0.6% organic acid mixture with ST, and 0.9% organic acid mixture with ST. Treatments were assigned to 20 pens with 40 chicks/pen and 4 replicates of each treatment. Chickens were challenged with 10(7) CFU/mL of nalidixic acid–resistant ST (ST(NAR)) 4-D posthatch. In the grower phase, feed conversion rate was significantly reduced in the 9% organic acid mixture compared with the PC. The body weight and body weight gain (BWG) were not affected either in the starter or grower phases. However, in the finisher phase, the nonchallenged NC had higher BWG than the PC (P < 0.05), whereas there were no differences in BWG among the NC and organic acid mixture fed groups. In addition, there was a significant effect of organic acid mixture on the colonization of cecal ST(NAR). At 9 dpi, cecal ST(NAR) was 3.28 log(10) in the PC that was reduced to 2.65 log(10) at 0.3%, 1.40 log(10) at 0.6%, and 0.84 log(10) in 0.9% organic acid mixture. At 24 dpi, cecal ST(NAR) recovery was 0.81, 0.99, 0.53, and 0.33 log(10) in the PC and 0.3, 0.6, and 0.9% organic acid mixture, respectively. Similarly, at 38 dpi, cecal ST(NAR) was 0.26, 0.11, 0.33, and 0 log(10) in the PC, 0.3, 0.6, and 0.9%, respectively. These results show that organic acid mixture can be one dietary strategy to control ST infection and maintain efficient growth performance.
format Online
Article
Text
id pubmed-7597380
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-75973802020-11-02 Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens Adhikari, Pratima Yadav, Sudhir Cosby, Douglas E. Cox, Nelson A. Jendza, Joshua A. Kim, Woo Kyun Poult Sci Metabolism and Nutrition Feed additives can be alternatives to antibiotics for routinely encountered pathogens in the poultry production. The objective of this study was to understand effects of organic acid mixture on growth parameters and Salmonella Typhimurium (ST) colonization in broilers. Organic acid mixture is a feed-grade buffered formic acid and sodium formate mixture (Amasil NA). A total of 800 1-day-old Cobb500 males were fed one of the five dietary treatments: a negative control diet without ST challenge (NC), positive control diet with ST challenge (PC), 0.3% organic acid mixture with ST, 0.6% organic acid mixture with ST, and 0.9% organic acid mixture with ST. Treatments were assigned to 20 pens with 40 chicks/pen and 4 replicates of each treatment. Chickens were challenged with 10(7) CFU/mL of nalidixic acid–resistant ST (ST(NAR)) 4-D posthatch. In the grower phase, feed conversion rate was significantly reduced in the 9% organic acid mixture compared with the PC. The body weight and body weight gain (BWG) were not affected either in the starter or grower phases. However, in the finisher phase, the nonchallenged NC had higher BWG than the PC (P < 0.05), whereas there were no differences in BWG among the NC and organic acid mixture fed groups. In addition, there was a significant effect of organic acid mixture on the colonization of cecal ST(NAR). At 9 dpi, cecal ST(NAR) was 3.28 log(10) in the PC that was reduced to 2.65 log(10) at 0.3%, 1.40 log(10) at 0.6%, and 0.84 log(10) in 0.9% organic acid mixture. At 24 dpi, cecal ST(NAR) recovery was 0.81, 0.99, 0.53, and 0.33 log(10) in the PC and 0.3, 0.6, and 0.9% organic acid mixture, respectively. Similarly, at 38 dpi, cecal ST(NAR) was 0.26, 0.11, 0.33, and 0 log(10) in the PC, 0.3, 0.6, and 0.9%, respectively. These results show that organic acid mixture can be one dietary strategy to control ST infection and maintain efficient growth performance. Elsevier 2020-03-12 /pmc/articles/PMC7597380/ /pubmed/32359600 http://dx.doi.org/10.1016/j.psj.2019.12.037 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Metabolism and Nutrition
Adhikari, Pratima
Yadav, Sudhir
Cosby, Douglas E.
Cox, Nelson A.
Jendza, Joshua A.
Kim, Woo Kyun
Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title_full Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title_fullStr Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title_full_unstemmed Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title_short Research Note: Effect of organic acid mixture on growth performance and Salmonella Typhimurium colonization in broiler chickens
title_sort research note: effect of organic acid mixture on growth performance and salmonella typhimurium colonization in broiler chickens
topic Metabolism and Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597380/
https://www.ncbi.nlm.nih.gov/pubmed/32359600
http://dx.doi.org/10.1016/j.psj.2019.12.037
work_keys_str_mv AT adhikaripratima researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens
AT yadavsudhir researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens
AT cosbydouglase researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens
AT coxnelsona researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens
AT jendzajoshuaa researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens
AT kimwookyun researchnoteeffectoforganicacidmixtureongrowthperformanceandsalmonellatyphimuriumcolonizationinbroilerchickens