Cargando…

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peña-Díaz, Samuel, Pujols, Jordi, Pinheiro, Francisca, Santos, Jaime, Pallarés, Irantzu, Navarro, Susanna, Conde-Gimenez, María, García, Jesús, Salvatella, Xavier, Dalfó, Esther, Sancho, Javier, Ventura, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597392/ https://www.ncbi.nlm.nih.gov/pubmed/33178678 http://dx.doi.org/10.3389/fbioe.2020.588947

Ejemplares similares

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization
por: Peña-Díaz, Samuel, et al.
Publicado: (2019)

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors
por: Pujols, Jordi, et al.
Publicado: (2017)

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
por: Santos, Jaime, et al.
Publicado: (2021)

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Computational prediction of protein aggregation: Advances in proteomics, conformation-specific algorithms and biotechnological applications
por: Santos, Jaime, et al.
Publicado: (2020)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains
por: Peña-Díaz, Samuel, et al.
Publicado: (2022)

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
por: Carija, Anita, et al.
Publicado: (2019)

The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region
por: Pujols, Jordi, et al.
Publicado: (2018)

aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation
por: Pintado-Grima, Carlos, et al.
Publicado: (2023)

One ring is sufficient to inhibit α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2021)

Prediction of "hot spots" of aggregation in disease-linked polypeptides
por: de Groot, Natalia Sánchez, et al.
Publicado: (2005)

Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structure
por: Marinelli, Patrizia, et al.
Publicado: (2016)

pH-Dependent Aggregation in Intrinsically Disordered Proteins Is Determined by Charge and Lipophilicity
por: Santos, Jaime, et al.
Publicado: (2020)

Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation
por: Zhao, Nanxia, et al.
Publicado: (2020)

The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core
por: Pallarès, Irantzu, et al.
Publicado: (2016)

LL-37 and CsgC exemplify the crosstalk between anti-amyloid, antimicrobial, and anti-biofilm protein activities
por: Santos, Jaime, et al.
Publicado: (2022)

Development of Small Molecules Targeting α-Synuclein Aggregation: A Promising Strategy to Treat Parkinson’s Disease
por: Peña-Díaz, Samuel, et al.
Publicado: (2023)

Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association
por: Santos, Jaime, et al.
Publicado: (2021)

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
por: Lázaro, Diana F., et al.
Publicado: (2016)

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease
por: Vittorio, Serena, et al.
Publicado: (2020)

D-arginine Enhances the Effect of Alpha-Amylase on Disassembling Actinomyces viscosus Biofilm
por: Li, Baosheng, et al.
Publicado: (2022)

Prion‐like proteins: from computational approaches to proteome‐wide analysis
por: Gil‐Garcia, Marcos, et al.
Publicado: (2021)

Minimalist spaces = Espacios minimalistas /
por: Mostaedi, Arian
Publicado: (2003)

Minimalist Mobile Robotics
por: Connell, Jonathan
Publicado: (2012)

Computational Assessment of Bacterial Protein Structures Indicates a Selection Against Aggregation
por: Carija, Anita, et al.
Publicado: (2019)

Self-assembly of human latexin into amyloid-like oligomers
por: Pallarés, Irantzu, et al.
Publicado: (2007)

The Impact of Hidden Structure on Aggregate Disassembly by Molecular Chaperones
por: Shoup, Daniel, et al.
Publicado: (2022)

Minimalist Approach to Perceptual Interactions
por: Lenay, Charles, et al.
Publicado: (2012)

Minimalistic Neutrino Mass Model
por: de Gouvea, Andre, et al.
Publicado: (2000)

Designing minimalist membrane proteins
por: Curnow, Paul
Publicado: (2019)

AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures
por: Zambrano, Rafael, et al.
Publicado: (2015)

T7 RNA polymerase non-specifically transcribes and induces disassembly of DNA nanostructures
por: Schaffter, Samuel W, et al.
Publicado: (2018)

Tracking Hypoxic Signaling within Encapsulated Cell Aggregates
por: Skiles, Matthew L., et al.
Publicado: (2011)

A3D database: structure-based predictions of protein aggregation for the human proteome
por: Badaczewska-Dawid, Aleksandra E, et al.
Publicado: (2022)

Minimalistic Musings about the Standard Model
por: Korthals Altes, Chris P
Publicado: (2021)

The minimalist architectures of viroporins and their therapeutic implications()
por: OuYang, Bo, et al.
Publicado: (2014)

Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation
por: López, Laura C., et al.
Publicado: (2016)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a3b4e8dk0a05hhpp9c42a31kor