KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma

Ewing sarcoma is an aggressive malignant neoplasm with high propensity for metastasis and poor clinical outcomes. The EWS/Fli1 oncofusion is the disease driver in > 90% of cases, but presents a difficult therapeutic target. Moreover, EWS/Fli1 plays a complex role in disease progression, with inhi...

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Detalles Bibliográficos
Autores principales: McCann, Tyler S., Parrish, Janet K., Hsieh, Joseph, Sechler, Marybeth, Sobral, Lays M., Self, Chelsea, Jones, Kenneth L., Goodspeed, Andrew, Costello, James C., Jedlicka, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597412/
https://www.ncbi.nlm.nih.gov/pubmed/33196691
http://dx.doi.org/10.18632/oncotarget.27737

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