Cargando…

EBV-EBNA1 constructs an immunosuppressive microenvironment for nasopharyngeal carcinoma by promoting the chemoattraction of Treg cells

BACKGROUND: Nasopharyngeal carcinoma (NPC) is primarily caused by the Epstein-Barr virus (EBV) infection in NPC endemic areas. EBNA1 is an EBV-encoded nuclear antigen, which plays a critical role in the maintenance and replication of EBV genome. However, the mechanisms of EBNA1-promoted NPC immune e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huo, Shaofen, Luo, Yunfan, Deng, Rui, Liu, Xiong, Wang, Jie, Wang, Lu, Zhang, Bao, Wang, Fan, Lu, Juan, Li, Xiangping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597532/ https://www.ncbi.nlm.nih.gov/pubmed/33122398 http://dx.doi.org/10.1136/jitc-2020-001588

Ejemplares similares

N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells
por: Sun, Yi, et al.
Publicado: (2021)

CD200 promotes immunosuppression in the pancreatic tumor microenvironment
por: Choueiry, Fouad, et al.
Publicado: (2020)

Mechanisms of Epstein‐Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma
por: Wang, Jie, et al.
Publicado: (2020)

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma
por: Shi, Yewen, et al.
Publicado: (2023)

Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment
por: Xu, Pengfei, et al.
Publicado: (2023)

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
por: Graziano, Vincenzo, et al.
Publicado: (2023)

TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer
por: Perez-Penco, Maria, et al.
Publicado: (2022)

Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL
por: Zhang, Tingting, et al.
Publicado: (2022)

Systematic comparison of plasma EBV DNA, anti‐EBV antibodies and miRNA levels for early detection and prognosis of nasopharyngeal carcinoma
por: Tan, Lu Ping, et al.
Publicado: (2019)

Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy
por: Liu, Hsin-Yu, et al.
Publicado: (2021)

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer
por: Ji, Dengbo, et al.
Publicado: (2020)

Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer
por: Bai, Fang, et al.
Publicado: (2020)

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
por: Wang, Zhaowei, et al.
Publicado: (2021)

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
por: Lu, Chia-Sing, et al.
Publicado: (2020)

Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models
por: Stirm, Kristin, et al.
Publicado: (2023)

Molecular Screening for Epstein-Barr virus (EBV): Detection of Genomic EBNA-1, EBNA-2, LMP-1, LMP-2 Among Vietnamese Patients with Nasopharyngeal Brush Samples
por: Lao, Thuan Duc, et al.
Publicado: (2017)

Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion
por: D'Alise, Anna Morena, et al.
Publicado: (2021)

Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis
por: Zhou, Yu-Fu, et al.
Publicado: (2021)

C1q(+) tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion
por: Zhang, Siyu, et al.
Publicado: (2023)

Vesicle‐bound EBV‐BART13‐3p miRNA in circulation distinguishes nasopharyngeal from other head and neck cancer and asymptomatic EBV‐infections
por: Ramayanti, Octavia, et al.
Publicado: (2018)

Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma
por: Tang, Weiwei, et al.
Publicado: (2023)

Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
por: Noyes, David, et al.
Publicado: (2022)

Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma
por: Zhou, Jiayi, et al.
Publicado: (2021)

THU499 The Mesenchymal Stem Cells Induce Immunosuppressive Microenvironment In Pituitary Tumors
por: Marrero-Rodríguez, Daniel, et al.
Publicado: (2023)

IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma
por: Weber, Rebekka, et al.
Publicado: (2020)

The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency
por: Styles, Christine T., et al.
Publicado: (2018)

Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families
por: Chang, C M, et al.
Publicado: (2012)

HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling
por: Arkhypov, Ihor, et al.
Publicado: (2022)

Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery
por: Zheng, Zening, et al.
Publicado: (2020)

2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1
por: Chen, Zhanfei, et al.
Publicado: (2020)

STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
por: Bitsch, Rebekka, et al.
Publicado: (2022)

BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
por: Liu, Wei, et al.
Publicado: (2022)

GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer
por: Wei, Jin-Li, et al.
Publicado: (2021)

Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization
por: Zhang, Qi, et al.
Publicado: (2022)

IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts
por: Chen, Lujun, et al.
Publicado: (2022)

T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer
por: Ni, Huanhe, et al.
Publicado: (2022)

PPARγ activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression
por: Prat, Mélissa, et al.
Publicado: (2023)

Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression
por: Finisguerra, Veronica, et al.
Publicado: (2023)

MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2
por: Jiang, Mengmeng, et al.
Publicado: (2022)

Novel Patterns of the Epstein-Barr Nuclear Antigen (EBNA-1) V-Val Subtype in EBV-associated Nasopharyngeal Carcinoma from Vietnam
por: Thuan, LD, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2s88gtiosid5n0pnis5nhfal8r