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Mesenchymal perivascular cells in immunity and disease

The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that thes...

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Detalles Bibliográficos
Autores principales: Benabid, Adam, Peduto, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597593/
https://www.ncbi.nlm.nih.gov/pubmed/32387900
http://dx.doi.org/10.1016/j.coi.2020.03.009
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author Benabid, Adam
Peduto, Lucie
author_facet Benabid, Adam
Peduto, Lucie
author_sort Benabid, Adam
collection PubMed
description The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized ‘effector’ mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases.
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spelling pubmed-75975932020-11-05 Mesenchymal perivascular cells in immunity and disease Benabid, Adam Peduto, Lucie Curr Opin Immunol Article The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized ‘effector’ mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases. Elsevier 2020-06 /pmc/articles/PMC7597593/ /pubmed/32387900 http://dx.doi.org/10.1016/j.coi.2020.03.009 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Benabid, Adam
Peduto, Lucie
Mesenchymal perivascular cells in immunity and disease
title Mesenchymal perivascular cells in immunity and disease
title_full Mesenchymal perivascular cells in immunity and disease
title_fullStr Mesenchymal perivascular cells in immunity and disease
title_full_unstemmed Mesenchymal perivascular cells in immunity and disease
title_short Mesenchymal perivascular cells in immunity and disease
title_sort mesenchymal perivascular cells in immunity and disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597593/
https://www.ncbi.nlm.nih.gov/pubmed/32387900
http://dx.doi.org/10.1016/j.coi.2020.03.009
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