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Mesenchymal perivascular cells in immunity and disease
The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that thes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597593/ https://www.ncbi.nlm.nih.gov/pubmed/32387900 http://dx.doi.org/10.1016/j.coi.2020.03.009 |
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author | Benabid, Adam Peduto, Lucie |
author_facet | Benabid, Adam Peduto, Lucie |
author_sort | Benabid, Adam |
collection | PubMed |
description | The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized ‘effector’ mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases. |
format | Online Article Text |
id | pubmed-7597593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75975932020-11-05 Mesenchymal perivascular cells in immunity and disease Benabid, Adam Peduto, Lucie Curr Opin Immunol Article The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized ‘effector’ mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases. Elsevier 2020-06 /pmc/articles/PMC7597593/ /pubmed/32387900 http://dx.doi.org/10.1016/j.coi.2020.03.009 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Benabid, Adam Peduto, Lucie Mesenchymal perivascular cells in immunity and disease |
title | Mesenchymal perivascular cells in immunity and disease |
title_full | Mesenchymal perivascular cells in immunity and disease |
title_fullStr | Mesenchymal perivascular cells in immunity and disease |
title_full_unstemmed | Mesenchymal perivascular cells in immunity and disease |
title_short | Mesenchymal perivascular cells in immunity and disease |
title_sort | mesenchymal perivascular cells in immunity and disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597593/ https://www.ncbi.nlm.nih.gov/pubmed/32387900 http://dx.doi.org/10.1016/j.coi.2020.03.009 |
work_keys_str_mv | AT benabidadam mesenchymalperivascularcellsinimmunityanddisease AT pedutolucie mesenchymalperivascularcellsinimmunityanddisease |