Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population

BACKGROUND: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. MATERIALS AND METHODS: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examin...

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Detalles Bibliográficos
Autores principales: Luan, Zhilin, Ming, Wenhua, Huo, Xiaoxiao, Yu, Jingwei, Wang, Bing, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Brief Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597706/
https://www.ncbi.nlm.nih.gov/pubmed/33165371
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_180_19
Descripción
Sumario:BACKGROUND: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. MATERIALS AND METHODS: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls. RESULTS: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs11926976-rs16823991) with schizophrenia. CONCLUSION: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia.

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