Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population

BACKGROUND: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. MATERIALS AND METHODS: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examin...

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Autores principales: Luan, Zhilin, Ming, Wenhua, Huo, Xiaoxiao, Yu, Jingwei, Wang, Bing, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Brief Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597706/
https://www.ncbi.nlm.nih.gov/pubmed/33165371
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_180_19
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author Luan, Zhilin
Ming, Wenhua
Huo, Xiaoxiao
Yu, Jingwei
Wang, Bing
Sun, Yang
author_facet Luan, Zhilin
Ming, Wenhua
Huo, Xiaoxiao
Yu, Jingwei
Wang, Bing
Sun, Yang
author_sort Luan, Zhilin
collection PubMed
description BACKGROUND: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. MATERIALS AND METHODS: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls. RESULTS: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs11926976-rs16823991) with schizophrenia. CONCLUSION: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia.
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spelling pubmed-75977062020-11-03 Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population Luan, Zhilin Ming, Wenhua Huo, Xiaoxiao Yu, Jingwei Wang, Bing Sun, Yang Indian J Psychiatry Brief Research Communication BACKGROUND: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. MATERIALS AND METHODS: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls. RESULTS: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs11926976-rs16823991) with schizophrenia. CONCLUSION: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia. Wolters Kluwer - Medknow 2020 2020-07-27 /pmc/articles/PMC7597706/ /pubmed/33165371 http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_180_19 Text en Copyright: © 2020 Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Brief Research Communication
Luan, Zhilin
Ming, Wenhua
Huo, Xiaoxiao
Yu, Jingwei
Wang, Bing
Sun, Yang
Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title_full Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title_fullStr Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title_full_unstemmed Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title_short Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population
title_sort genetic association of the human gap43 gene with schizophrenia in a northeast chinese han population
topic Brief Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597706/
https://www.ncbi.nlm.nih.gov/pubmed/33165371
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_180_19
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