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Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma

Electroporation is a technique that increases the uptake of chemotherapeutic drugs by tumors. Electrochemotherapy (ECT) has been successfully used to treat solid tumors. Recently, novel applications have been explored in the treatment of visceral tumors. This report aimed to describe the ECT as an a...

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Autores principales: Dos Anjos, Denner Santos, Buosi, Rafaela Guedes, Roratto, Isadora, Mesquita, Luciane dos Reis, Matiz, Oscar Rodrigo Sierra, Fonseca-Alves, Carlos Eduardo, Spugnini, Enrico Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Urmia University Press 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597792/
https://www.ncbi.nlm.nih.gov/pubmed/33133468
http://dx.doi.org/10.30466/vrf.2020.113009.2688
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author Dos Anjos, Denner Santos
Buosi, Rafaela Guedes
Roratto, Isadora
Mesquita, Luciane dos Reis
Matiz, Oscar Rodrigo Sierra
Fonseca-Alves, Carlos Eduardo
Spugnini, Enrico Pierluigi
author_facet Dos Anjos, Denner Santos
Buosi, Rafaela Guedes
Roratto, Isadora
Mesquita, Luciane dos Reis
Matiz, Oscar Rodrigo Sierra
Fonseca-Alves, Carlos Eduardo
Spugnini, Enrico Pierluigi
author_sort Dos Anjos, Denner Santos
collection PubMed
description Electroporation is a technique that increases the uptake of chemotherapeutic drugs by tumors. Electrochemotherapy (ECT) has been successfully used to treat solid tumors. Recently, novel applications have been explored in the treatment of visceral tumors. This report aimed to describe the ECT as an approach to vesical carcinoma in three dogs. The patients received ECT with bleomycin as an intravenous bolus and intra-lesional cisplatin (cases 2 and 3). The ECT was performed by electroporator (Onkodisruptor(®)) using a plate and/or a single pair needle array electrode. Case 1 was a 7-year-old female Pitbull dog with a history of hematuria and stranguria. The ECT was performed during cystotomy using a single pair array electrode. However, the patient developed uroabdomen two days post-ECT and died 5 days later. Case 2 was a 12-year-old female Poodle dog with hematuria, dysuria, and pollakiuria. Cystotomy and ECT were performed using plate array electrodes. Complete remission of the intra-luminal mass was observed 11 days post-ECT. However, 21 days after the procedure, an acute unilateral renal failure occurred possibly due to a neoplastic embolus into the right ureter leading to kidney hydronephrosis, and the patient was euthanized. Case 3 was a 10-year-old female Cocker dog with hematuria and pollakiuria. The patient was fully competent after ECT without clinical signs of pollakiuria and recovered from hematuria 7 days post-ECT. The bladder returned to normal status 28 days post-ECT. The ECT was not able to increase the overall survival of the patients evaluated and should be indicated carefully.
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spelling pubmed-75977922020-10-31 Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma Dos Anjos, Denner Santos Buosi, Rafaela Guedes Roratto, Isadora Mesquita, Luciane dos Reis Matiz, Oscar Rodrigo Sierra Fonseca-Alves, Carlos Eduardo Spugnini, Enrico Pierluigi Vet Res Forum Clinical Report Electroporation is a technique that increases the uptake of chemotherapeutic drugs by tumors. Electrochemotherapy (ECT) has been successfully used to treat solid tumors. Recently, novel applications have been explored in the treatment of visceral tumors. This report aimed to describe the ECT as an approach to vesical carcinoma in three dogs. The patients received ECT with bleomycin as an intravenous bolus and intra-lesional cisplatin (cases 2 and 3). The ECT was performed by electroporator (Onkodisruptor(®)) using a plate and/or a single pair needle array electrode. Case 1 was a 7-year-old female Pitbull dog with a history of hematuria and stranguria. The ECT was performed during cystotomy using a single pair array electrode. However, the patient developed uroabdomen two days post-ECT and died 5 days later. Case 2 was a 12-year-old female Poodle dog with hematuria, dysuria, and pollakiuria. Cystotomy and ECT were performed using plate array electrodes. Complete remission of the intra-luminal mass was observed 11 days post-ECT. However, 21 days after the procedure, an acute unilateral renal failure occurred possibly due to a neoplastic embolus into the right ureter leading to kidney hydronephrosis, and the patient was euthanized. Case 3 was a 10-year-old female Cocker dog with hematuria and pollakiuria. The patient was fully competent after ECT without clinical signs of pollakiuria and recovered from hematuria 7 days post-ECT. The bladder returned to normal status 28 days post-ECT. The ECT was not able to increase the overall survival of the patients evaluated and should be indicated carefully. Urmia University Press 2020 2020-09-15 /pmc/articles/PMC7597792/ /pubmed/33133468 http://dx.doi.org/10.30466/vrf.2020.113009.2688 Text en © 2020 Urmia University. All rights reserved This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Clinical Report
Dos Anjos, Denner Santos
Buosi, Rafaela Guedes
Roratto, Isadora
Mesquita, Luciane dos Reis
Matiz, Oscar Rodrigo Sierra
Fonseca-Alves, Carlos Eduardo
Spugnini, Enrico Pierluigi
Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title_full Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title_fullStr Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title_full_unstemmed Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title_short Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
title_sort preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma
topic Clinical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597792/
https://www.ncbi.nlm.nih.gov/pubmed/33133468
http://dx.doi.org/10.30466/vrf.2020.113009.2688
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