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Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to d...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597927/ https://www.ncbi.nlm.nih.gov/pubmed/32889171 http://dx.doi.org/10.1016/j.nbd.2020.105064 |
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author | Wang, Huei Bin Tahara, Yu Luk, Shu Hon Christopher Kim, Yoon-Sik Hitchcock, Olivia N. Kaswan, Zoe A. MacDowell Kim, Yang In Block, Gene D. Ghiani, Cristina A. Loh, Dawn H. Colwell, Christopher S. |
author_facet | Wang, Huei Bin Tahara, Yu Luk, Shu Hon Christopher Kim, Yoon-Sik Hitchcock, Olivia N. Kaswan, Zoe A. MacDowell Kim, Yang In Block, Gene D. Ghiani, Cristina A. Loh, Dawn H. Colwell, Christopher S. |
author_sort | Wang, Huei Bin |
collection | PubMed |
description | Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD. |
format | Online Article Text |
id | pubmed-7597927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-75979272020-11-01 Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder Wang, Huei Bin Tahara, Yu Luk, Shu Hon Christopher Kim, Yoon-Sik Hitchcock, Olivia N. Kaswan, Zoe A. MacDowell Kim, Yang In Block, Gene D. Ghiani, Cristina A. Loh, Dawn H. Colwell, Christopher S. Neurobiol Dis Article Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD. 2020-09-02 2020-11 /pmc/articles/PMC7597927/ /pubmed/32889171 http://dx.doi.org/10.1016/j.nbd.2020.105064 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Wang, Huei Bin Tahara, Yu Luk, Shu Hon Christopher Kim, Yoon-Sik Hitchcock, Olivia N. Kaswan, Zoe A. MacDowell Kim, Yang In Block, Gene D. Ghiani, Cristina A. Loh, Dawn H. Colwell, Christopher S. Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title_full | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title_fullStr | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title_full_unstemmed | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title_short | Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder |
title_sort | melatonin treatment of repetitive behavioral deficits in the cntnap2 mouse model of autism spectrum disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597927/ https://www.ncbi.nlm.nih.gov/pubmed/32889171 http://dx.doi.org/10.1016/j.nbd.2020.105064 |
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