Low frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia

TP53 mutations (TP53mut) in AML patients associate with poor prognosis that may affect therapy and outcome. In addition to TP53 mut patients, TCGA AML patient sequencing data shows that there are around 3% of patients have detectable low frequency TP53mut reads. Importantly, these patients showed wo...

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Detalles Bibliográficos
Autores principales: Yan, Bowen, Chen, Qinwei, Xu, Jianfeng, Li, Wei, Xu, Bing, Qiu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597970/
https://www.ncbi.nlm.nih.gov/pubmed/31988438
http://dx.doi.org/10.1038/s41375-020-0710-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597970/
https://www.ncbi.nlm.nih.gov/pubmed/31988438
http://dx.doi.org/10.1038/s41375-020-0710-7

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