Cargando…
Low frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia
TP53 mutations (TP53mut) in AML patients associate with poor prognosis that may affect therapy and outcome. In addition to TP53 mut patients, TCGA AML patient sequencing data shows that there are around 3% of patients have detectable low frequency TP53mut reads. Importantly, these patients showed wo...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597970/ https://www.ncbi.nlm.nih.gov/pubmed/31988438 http://dx.doi.org/10.1038/s41375-020-0710-7 |