COVID-19: a potential driver of immune-mediated breast cancer recurrence?

Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Francescangeli, Federica, De Angelis, Maria Laura, Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598231/
https://www.ncbi.nlm.nih.gov/pubmed/33126915
http://dx.doi.org/10.1186/s13058-020-01360-0
_version_ 1783602545933942784
author Francescangeli, Federica
De Angelis, Maria Laura
Zeuner, Ann
author_facet Francescangeli, Federica
De Angelis, Maria Laura
Zeuner, Ann
author_sort Francescangeli, Federica
collection PubMed
description Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.
format Online
Article
Text
id pubmed-7598231
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-75982312020-11-02 COVID-19: a potential driver of immune-mediated breast cancer recurrence? Francescangeli, Federica De Angelis, Maria Laura Zeuner, Ann Breast Cancer Res Viewpoint Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse. BioMed Central 2020-10-30 2020 /pmc/articles/PMC7598231/ /pubmed/33126915 http://dx.doi.org/10.1186/s13058-020-01360-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Viewpoint
Francescangeli, Federica
De Angelis, Maria Laura
Zeuner, Ann
COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title_full COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title_fullStr COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title_full_unstemmed COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title_short COVID-19: a potential driver of immune-mediated breast cancer recurrence?
title_sort covid-19: a potential driver of immune-mediated breast cancer recurrence?
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598231/
https://www.ncbi.nlm.nih.gov/pubmed/33126915
http://dx.doi.org/10.1186/s13058-020-01360-0
work_keys_str_mv AT francescangelifederica covid19apotentialdriverofimmunemediatedbreastcancerrecurrence
AT deangelismarialaura covid19apotentialdriverofimmunemediatedbreastcancerrecurrence
AT zeunerann covid19apotentialdriverofimmunemediatedbreastcancerrecurrence

Ejemplares similares