pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—tria...

Descripción completa

Detalles Bibliográficos
Autores principales: Apartsin, Evgeny, Knauer, Nadezhda, Arkhipova, Valeria, Pashkina, Ekaterina, Aktanova, Alina, Poletaeva, Julia, Sánchez-Nieves, Javier, de la Mata, Francisco Javier, Gómez, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598245/
https://www.ncbi.nlm.nih.gov/pubmed/32977594
http://dx.doi.org/10.3390/nano10101899
_version_ 1783602550497345536
author Apartsin, Evgeny
Knauer, Nadezhda
Arkhipova, Valeria
Pashkina, Ekaterina
Aktanova, Alina
Poletaeva, Julia
Sánchez-Nieves, Javier
de la Mata, Francisco Javier
Gómez, Rafael
author_facet Apartsin, Evgeny
Knauer, Nadezhda
Arkhipova, Valeria
Pashkina, Ekaterina
Aktanova, Alina
Poletaeva, Julia
Sánchez-Nieves, Javier
de la Mata, Francisco Javier
Gómez, Rafael
author_sort Apartsin, Evgeny
collection PubMed
description Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
format Online
Article
Text
id pubmed-7598245
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75982452020-10-31 pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery Apartsin, Evgeny Knauer, Nadezhda Arkhipova, Valeria Pashkina, Ekaterina Aktanova, Alina Poletaeva, Julia Sánchez-Nieves, Javier de la Mata, Francisco Javier Gómez, Rafael Nanomaterials (Basel) Article Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy. MDPI 2020-09-23 /pmc/articles/PMC7598245/ /pubmed/32977594 http://dx.doi.org/10.3390/nano10101899 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Apartsin, Evgeny
Knauer, Nadezhda
Arkhipova, Valeria
Pashkina, Ekaterina
Aktanova, Alina
Poletaeva, Julia
Sánchez-Nieves, Javier
de la Mata, Francisco Javier
Gómez, Rafael
pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_full pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_fullStr pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_full_unstemmed pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_short pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_sort ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598245/
https://www.ncbi.nlm.nih.gov/pubmed/32977594
http://dx.doi.org/10.3390/nano10101899
work_keys_str_mv AT apartsinevgeny phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT knauernadezhda phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT arkhipovavaleria phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT pashkinaekaterina phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT aktanovaalina phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT poletaevajulia phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT sancheznievesjavier phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT delamatafranciscojavier phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery
AT gomezrafael phsensitivedendrimersomesofhybridtriazinecarbosilanedendriticamphiphilessmartvehiclesfordrugdelivery

Ejemplares similares