Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role...

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Autores principales: Bo, Marco, Jasemi, Seyedesomaye, Uras, Giuseppe, Erre, Gian Luca, Passiu, Giuseppe, Sechi, Leonardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598258/
https://www.ncbi.nlm.nih.gov/pubmed/32977590
http://dx.doi.org/10.3390/microorganisms8101459
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author Bo, Marco
Jasemi, Seyedesomaye
Uras, Giuseppe
Erre, Gian Luca
Passiu, Giuseppe
Sechi, Leonardo A.
author_facet Bo, Marco
Jasemi, Seyedesomaye
Uras, Giuseppe
Erre, Gian Luca
Passiu, Giuseppe
Sechi, Leonardo A.
author_sort Bo, Marco
collection PubMed
description Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA.
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spelling pubmed-75982582020-10-31 Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria Bo, Marco Jasemi, Seyedesomaye Uras, Giuseppe Erre, Gian Luca Passiu, Giuseppe Sechi, Leonardo A. Microorganisms Review Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA. MDPI 2020-09-23 /pmc/articles/PMC7598258/ /pubmed/32977590 http://dx.doi.org/10.3390/microorganisms8101459 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bo, Marco
Jasemi, Seyedesomaye
Uras, Giuseppe
Erre, Gian Luca
Passiu, Giuseppe
Sechi, Leonardo A.
Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title_full Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title_fullStr Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title_full_unstemmed Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title_short Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria
title_sort role of infections in the pathogenesis of rheumatoid arthritis: focus on mycobacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598258/
https://www.ncbi.nlm.nih.gov/pubmed/32977590
http://dx.doi.org/10.3390/microorganisms8101459
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