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MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals

According to PubMed, roughly 10% of the annually added publications are describing findings from the small animal model (mice and rats), including investigations in the field of muscle physiology and training. A subset of this research requires neural stimulation with flexible adjustments of stimula...

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Autores principales: Bijak, Manfred, Schmoll, Martin, Jarvis, Jonathan C., Unger, Ewald, Lanmüller, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598460/
https://www.ncbi.nlm.nih.gov/pubmed/33125415
http://dx.doi.org/10.1371/journal.pone.0241638
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author Bijak, Manfred
Schmoll, Martin
Jarvis, Jonathan C.
Unger, Ewald
Lanmüller, Hermann
author_facet Bijak, Manfred
Schmoll, Martin
Jarvis, Jonathan C.
Unger, Ewald
Lanmüller, Hermann
author_sort Bijak, Manfred
collection PubMed
description According to PubMed, roughly 10% of the annually added publications are describing findings from the small animal model (mice and rats), including investigations in the field of muscle physiology and training. A subset of this research requires neural stimulation with flexible adjustments of stimulation parameters, highlighting the need for reliable implantable electrical stimulators, small enough (~1 cm(3)), that even mice can tolerate them without impairing their movement. The MiniVStimA is a battery-powered implant for nerve stimulation with an outer diameter of 15 mm and an encapsulated volume of 1.2 cm(3) in its smallest variation. It can be pre-programmed according to the experimental protocol and controlled after implantation with a magnet. It delivers constant current charge-balanced monophasic rectangular pulses up to 2 mA and 1 ms phase width (1 kΩ load). The circuitry is optimized for small volume and energy efficiency. Due to the variation of the internal oscillator (31 kHz ± 10%), calibration measures must be implemented during the manufacturing process, which can reduce the deviation of the frequency related parameters down to ± 1%. The expected lifetime of the smaller (larger) version is 100 (480) days for stimulation with 7 Hz all day and 10 (48) days for stimulation with 100 Hz. Devices with complex stimulation patterns for nerve stimulation have been successfully used in two in-vivo studies, lasting up to nine weeks. The implant worked fully self-contained while the animal stayed in its familiar environment. External components are not required during the entire time.
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spelling pubmed-75984602020-11-03 MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals Bijak, Manfred Schmoll, Martin Jarvis, Jonathan C. Unger, Ewald Lanmüller, Hermann PLoS One Research Article According to PubMed, roughly 10% of the annually added publications are describing findings from the small animal model (mice and rats), including investigations in the field of muscle physiology and training. A subset of this research requires neural stimulation with flexible adjustments of stimulation parameters, highlighting the need for reliable implantable electrical stimulators, small enough (~1 cm(3)), that even mice can tolerate them without impairing their movement. The MiniVStimA is a battery-powered implant for nerve stimulation with an outer diameter of 15 mm and an encapsulated volume of 1.2 cm(3) in its smallest variation. It can be pre-programmed according to the experimental protocol and controlled after implantation with a magnet. It delivers constant current charge-balanced monophasic rectangular pulses up to 2 mA and 1 ms phase width (1 kΩ load). The circuitry is optimized for small volume and energy efficiency. Due to the variation of the internal oscillator (31 kHz ± 10%), calibration measures must be implemented during the manufacturing process, which can reduce the deviation of the frequency related parameters down to ± 1%. The expected lifetime of the smaller (larger) version is 100 (480) days for stimulation with 7 Hz all day and 10 (48) days for stimulation with 100 Hz. Devices with complex stimulation patterns for nerve stimulation have been successfully used in two in-vivo studies, lasting up to nine weeks. The implant worked fully self-contained while the animal stayed in its familiar environment. External components are not required during the entire time. Public Library of Science 2020-10-30 /pmc/articles/PMC7598460/ /pubmed/33125415 http://dx.doi.org/10.1371/journal.pone.0241638 Text en © 2020 Bijak et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bijak, Manfred
Schmoll, Martin
Jarvis, Jonathan C.
Unger, Ewald
Lanmüller, Hermann
MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title_full MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title_fullStr MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title_full_unstemmed MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title_short MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals
title_sort minivstima: a miniaturized easy to use implantable electrical stimulator for small laboratory animals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598460/
https://www.ncbi.nlm.nih.gov/pubmed/33125415
http://dx.doi.org/10.1371/journal.pone.0241638
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