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Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute
BACKGROUND: Prostate cancer is the second most common cancer among men in Uganda, with over 2086 incident cases in 2018. This study’s objective was to report the clinical characteristics and primary management of men diagnosed with prostate cancer at the Uganda Cancer Institute from 1(st) January 20...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598473/ https://www.ncbi.nlm.nih.gov/pubmed/33125383 http://dx.doi.org/10.1371/journal.pone.0236458 |
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author | Katongole, Paul Sande, Obondo J. Yusuf, Mulumba Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon |
author_facet | Katongole, Paul Sande, Obondo J. Yusuf, Mulumba Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon |
author_sort | Katongole, Paul |
collection | PubMed |
description | BACKGROUND: Prostate cancer is the second most common cancer among men in Uganda, with over 2086 incident cases in 2018. This study’s objective was to report the clinical characteristics and primary management of men diagnosed with prostate cancer at the Uganda Cancer Institute from 1(st) January 2015 to 31(st) December 2019. METHODS: Records from all men diagnosed with Prostate cancer at the Uganda Cancer Institute from 1(st) January 2015 to 31(st) December 2019 were reviewed. Clinical characteristics and primary treatment were recorded. Risk categorization was done using the European Society for Medical Oncology prostate cancer risk group classification. RESULTS: A total of 874 medical records for men diagnosed with prostate cancer was retrieved. The median age was 70 years (interquartile range 64–77). In this study, 501 (57.32%) patients had localized disease. Among patients with localized disease, 2 (0.23%) were classified as low-risk, 5 (0.53%) as intermediate-risk, and 494 (56.52%) as high-risk. Three hundred seventy-three (373) patients had metastatic disease at diagnosis. Among patients with distant metastases, the most common site of metastases was bone 143 (16.36%), followed by spinal cord 54 (6.18%), abdomen 22 (2.52%), and lungs 14 (1.60%). Regarding the primary treatment options majority of the patients were on chemotherapy 384(43.94%) followed by hormonal therapy 336 (38.44%) and radiotherapy 127 (14.53%). CONCLUSION: The majority of the patients diagnosed with prostate cancer at the Uganda Cancer Institute presented with advanced disease. The primary treatments were mostly chemotherapy, hormonal therapy, and radiotherapy. There is a need to improve prostate cancer screening in regional health care facilities and the communities to enhance early detection and management of prostate cancer. |
format | Online Article Text |
id | pubmed-7598473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75984732020-11-03 Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute Katongole, Paul Sande, Obondo J. Yusuf, Mulumba Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon PLoS One Research Article BACKGROUND: Prostate cancer is the second most common cancer among men in Uganda, with over 2086 incident cases in 2018. This study’s objective was to report the clinical characteristics and primary management of men diagnosed with prostate cancer at the Uganda Cancer Institute from 1(st) January 2015 to 31(st) December 2019. METHODS: Records from all men diagnosed with Prostate cancer at the Uganda Cancer Institute from 1(st) January 2015 to 31(st) December 2019 were reviewed. Clinical characteristics and primary treatment were recorded. Risk categorization was done using the European Society for Medical Oncology prostate cancer risk group classification. RESULTS: A total of 874 medical records for men diagnosed with prostate cancer was retrieved. The median age was 70 years (interquartile range 64–77). In this study, 501 (57.32%) patients had localized disease. Among patients with localized disease, 2 (0.23%) were classified as low-risk, 5 (0.53%) as intermediate-risk, and 494 (56.52%) as high-risk. Three hundred seventy-three (373) patients had metastatic disease at diagnosis. Among patients with distant metastases, the most common site of metastases was bone 143 (16.36%), followed by spinal cord 54 (6.18%), abdomen 22 (2.52%), and lungs 14 (1.60%). Regarding the primary treatment options majority of the patients were on chemotherapy 384(43.94%) followed by hormonal therapy 336 (38.44%) and radiotherapy 127 (14.53%). CONCLUSION: The majority of the patients diagnosed with prostate cancer at the Uganda Cancer Institute presented with advanced disease. The primary treatments were mostly chemotherapy, hormonal therapy, and radiotherapy. There is a need to improve prostate cancer screening in regional health care facilities and the communities to enhance early detection and management of prostate cancer. Public Library of Science 2020-10-30 /pmc/articles/PMC7598473/ /pubmed/33125383 http://dx.doi.org/10.1371/journal.pone.0236458 Text en © 2020 Katongole et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Katongole, Paul Sande, Obondo J. Yusuf, Mulumba Joloba, Moses Reynolds, Steven J. Niyonzima, Nixon Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title | Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title_full | Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title_fullStr | Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title_full_unstemmed | Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title_short | Clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the Uganda Cancer Institute |
title_sort | clinical characteristics and primary management of patients diagnosed with prostate cancer between 2015 and 2019 at the uganda cancer institute |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598473/ https://www.ncbi.nlm.nih.gov/pubmed/33125383 http://dx.doi.org/10.1371/journal.pone.0236458 |
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