Cargando…

Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)

BACKGROUND: Leprosy transmission is ongoing; globally and within Bangladesh. Household contacts of leprosy cases are at increased risk of leprosy development. Identification of household contacts at highest risk would optimize this process. METHODS: The temporal pattern of new case presentation amon...

Descripción completa

Detalles Bibliográficos
Autores principales: Quilter, Emily E. V., Butlin, C. Ruth, Singh, Surendra, Alam, Khorshed, Lockwood, Diana N. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598483/
https://www.ncbi.nlm.nih.gov/pubmed/33125403
http://dx.doi.org/10.1371/journal.pntd.0008687
_version_ 1783602623068241920
author Quilter, Emily E. V.
Butlin, C. Ruth
Singh, Surendra
Alam, Khorshed
Lockwood, Diana N. J.
author_facet Quilter, Emily E. V.
Butlin, C. Ruth
Singh, Surendra
Alam, Khorshed
Lockwood, Diana N. J.
author_sort Quilter, Emily E. V.
collection PubMed
description BACKGROUND: Leprosy transmission is ongoing; globally and within Bangladesh. Household contacts of leprosy cases are at increased risk of leprosy development. Identification of household contacts at highest risk would optimize this process. METHODS: The temporal pattern of new case presentation amongst household contacts was documented in the COCOA (Contact Cohort Analysis) study. The COCOA study actively examined household contacts of confirmed leprosy index cases identified in 1995, and 2000–2014, to provide evidence for timings of contact examination policies. Data was available on 9527 index cases and 38303 household contacts. 666 household contacts were diagnosed with leprosy throughout the follow-up (maximum follow-up of 21 years). Risk factors for leprosy development within the data analysed, were identified using Cox proportional hazard regression. FINDINGS: The dominant risk factor for household contacts developing leprosy was having a highly skin smear positive index case in the household. As the grading of initial slit skin smear of the index case increased from negative to high positive (4–6), the hazard of their associated household contacts developing leprosy increases by 3.14 times (p<0.001). Being a blood relative was not a risk factor, no gender differences in susceptibility were found. INTERPRETATION: We found a dominance of a single variable predicting risk for leprosy transmission–skin smear positive index cases. A small number of cases are maintaining transmission in the household setting. Focus should be performing contact examinations on these households and detecting new skin smear positive index cases. Conducting slit-skin smears on new cases is needed for predicting risk; such services need supporting. If skin smear positive cases are sustaining leprosy infection within the household setting, the administration of single-dose rifampicin (SDR) to household contacts as the sole intervention in Bangladesh will not be effective.
format Online
Article
Text
id pubmed-7598483
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-75984832020-11-03 Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA) Quilter, Emily E. V. Butlin, C. Ruth Singh, Surendra Alam, Khorshed Lockwood, Diana N. J. PLoS Negl Trop Dis Research Article BACKGROUND: Leprosy transmission is ongoing; globally and within Bangladesh. Household contacts of leprosy cases are at increased risk of leprosy development. Identification of household contacts at highest risk would optimize this process. METHODS: The temporal pattern of new case presentation amongst household contacts was documented in the COCOA (Contact Cohort Analysis) study. The COCOA study actively examined household contacts of confirmed leprosy index cases identified in 1995, and 2000–2014, to provide evidence for timings of contact examination policies. Data was available on 9527 index cases and 38303 household contacts. 666 household contacts were diagnosed with leprosy throughout the follow-up (maximum follow-up of 21 years). Risk factors for leprosy development within the data analysed, were identified using Cox proportional hazard regression. FINDINGS: The dominant risk factor for household contacts developing leprosy was having a highly skin smear positive index case in the household. As the grading of initial slit skin smear of the index case increased from negative to high positive (4–6), the hazard of their associated household contacts developing leprosy increases by 3.14 times (p<0.001). Being a blood relative was not a risk factor, no gender differences in susceptibility were found. INTERPRETATION: We found a dominance of a single variable predicting risk for leprosy transmission–skin smear positive index cases. A small number of cases are maintaining transmission in the household setting. Focus should be performing contact examinations on these households and detecting new skin smear positive index cases. Conducting slit-skin smears on new cases is needed for predicting risk; such services need supporting. If skin smear positive cases are sustaining leprosy infection within the household setting, the administration of single-dose rifampicin (SDR) to household contacts as the sole intervention in Bangladesh will not be effective. Public Library of Science 2020-10-30 /pmc/articles/PMC7598483/ /pubmed/33125403 http://dx.doi.org/10.1371/journal.pntd.0008687 Text en © 2020 Quilter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Quilter, Emily E. V.
Butlin, C. Ruth
Singh, Surendra
Alam, Khorshed
Lockwood, Diana N. J.
Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title_full Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title_fullStr Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title_full_unstemmed Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title_short Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)
title_sort patients with skin smear positive leprosy in bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (cocoa)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598483/
https://www.ncbi.nlm.nih.gov/pubmed/33125403
http://dx.doi.org/10.1371/journal.pntd.0008687
work_keys_str_mv AT quilteremilyev patientswithskinsmearpositiveleprosyinbangladesharethemainriskfactorforleprosydevelopment21yearfollowupinthehouseholdcontactstudycocoa
AT butlincruth patientswithskinsmearpositiveleprosyinbangladesharethemainriskfactorforleprosydevelopment21yearfollowupinthehouseholdcontactstudycocoa
AT singhsurendra patientswithskinsmearpositiveleprosyinbangladesharethemainriskfactorforleprosydevelopment21yearfollowupinthehouseholdcontactstudycocoa
AT alamkhorshed patientswithskinsmearpositiveleprosyinbangladesharethemainriskfactorforleprosydevelopment21yearfollowupinthehouseholdcontactstudycocoa
AT lockwooddiananj patientswithskinsmearpositiveleprosyinbangladesharethemainriskfactorforleprosydevelopment21yearfollowupinthehouseholdcontactstudycocoa