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Investigation of light-induced lacrimation and pupillary responses in episodic migraine

The purpose of this pilot study was to investigate the light-induced pupillary and lacrimation responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in migraine. Ten participants with episodic migraine and normal tear production, as well as eleven visually normal control...

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Autores principales: Zivcevska, Marija, Lei, Shaobo, Blakeman, Alan, MacGregor, Daune, Goltz, Herbert C., Wong, Agnes M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598498/
https://www.ncbi.nlm.nih.gov/pubmed/33125423
http://dx.doi.org/10.1371/journal.pone.0241490
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author Zivcevska, Marija
Lei, Shaobo
Blakeman, Alan
MacGregor, Daune
Goltz, Herbert C.
Wong, Agnes M. F.
author_facet Zivcevska, Marija
Lei, Shaobo
Blakeman, Alan
MacGregor, Daune
Goltz, Herbert C.
Wong, Agnes M. F.
author_sort Zivcevska, Marija
collection PubMed
description The purpose of this pilot study was to investigate the light-induced pupillary and lacrimation responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in migraine. Ten participants with episodic migraine and normal tear production, as well as eleven visually normal controls participated in this study. Following an initial baseline trial (no light flash), participants received seven incremental and alternating red and blue light flashes. Pupillometry recording of the left eye and a 1-min anesthetized Schirmer’s test of the right eye (using 0.5% proparacaine) were performed simultaneously. Intrinsic and extrinsic ipRGC photoactivities did not differ between migraine participants and controls across all intensities and wavelengths. Migraine participants, however, had significantly lower lacrimation than controls following the highest blue intensity. A positive correlation was found between melanopsin-driven post-illumination pupillary responses and lacrimation following blue stimulation in both groups. Our results show that participants with self-reported photophobia have normal ipRGC-driven responses, suggesting that photophobia and pupillary function may be mediated by distinct ipRGC circuits. The positive correlation between melanopsin-driven pupillary responses and light-induced lacrimation suggests the afferent arm of the light-induced lacrimation reflex is melanopsin-mediated and functions normally in migraine. Lastly, the reduced melanopsin-mediated lacrimation at the highest stimulus suggests the efferent arm of the lacrimation reflex is attenuated under certain conditions, which may be a harbinger of dry eye in migraine.
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spelling pubmed-75984982020-11-03 Investigation of light-induced lacrimation and pupillary responses in episodic migraine Zivcevska, Marija Lei, Shaobo Blakeman, Alan MacGregor, Daune Goltz, Herbert C. Wong, Agnes M. F. PLoS One Research Article The purpose of this pilot study was to investigate the light-induced pupillary and lacrimation responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in migraine. Ten participants with episodic migraine and normal tear production, as well as eleven visually normal controls participated in this study. Following an initial baseline trial (no light flash), participants received seven incremental and alternating red and blue light flashes. Pupillometry recording of the left eye and a 1-min anesthetized Schirmer’s test of the right eye (using 0.5% proparacaine) were performed simultaneously. Intrinsic and extrinsic ipRGC photoactivities did not differ between migraine participants and controls across all intensities and wavelengths. Migraine participants, however, had significantly lower lacrimation than controls following the highest blue intensity. A positive correlation was found between melanopsin-driven post-illumination pupillary responses and lacrimation following blue stimulation in both groups. Our results show that participants with self-reported photophobia have normal ipRGC-driven responses, suggesting that photophobia and pupillary function may be mediated by distinct ipRGC circuits. The positive correlation between melanopsin-driven pupillary responses and light-induced lacrimation suggests the afferent arm of the light-induced lacrimation reflex is melanopsin-mediated and functions normally in migraine. Lastly, the reduced melanopsin-mediated lacrimation at the highest stimulus suggests the efferent arm of the lacrimation reflex is attenuated under certain conditions, which may be a harbinger of dry eye in migraine. Public Library of Science 2020-10-30 /pmc/articles/PMC7598498/ /pubmed/33125423 http://dx.doi.org/10.1371/journal.pone.0241490 Text en © 2020 Zivcevska et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zivcevska, Marija
Lei, Shaobo
Blakeman, Alan
MacGregor, Daune
Goltz, Herbert C.
Wong, Agnes M. F.
Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title_full Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title_fullStr Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title_full_unstemmed Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title_short Investigation of light-induced lacrimation and pupillary responses in episodic migraine
title_sort investigation of light-induced lacrimation and pupillary responses in episodic migraine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598498/
https://www.ncbi.nlm.nih.gov/pubmed/33125423
http://dx.doi.org/10.1371/journal.pone.0241490
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