Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the e...

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Detalles Bibliográficos
Autores principales: Carpinteiro, Alexander, Edwards, Michael J., Hoffmann, Markus, Kochs, Georg, Gripp, Barbara, Weigang, Sebastian, Adams, Constantin, Carpinteiro, Elisa, Gulbins, Anne, Keitsch, Simone, Sehl, Carolin, Soddemann, Matthias, Wilker, Barbara, Kamler, Markus, Bertsch, Thomas, Lang, Karl S., Patel, Sameer, Wilson, Gregory C., Walter, Silke, Hengel, Hartmut, Pöhlmann, Stefan, Lang, Philipp A., Kornhuber, Johannes, Becker, Katrin Anne, Ahmad, Syed A., Fassbender, Klaus, Gulbins, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598530/
https://www.ncbi.nlm.nih.gov/pubmed/33163980
http://dx.doi.org/10.1016/j.xcrm.2020.100142

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