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A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019

(1) Background: Candida auris has been reported as emerging yeast pathogen that can cause invasive bloodstream infections in healthcare settings. It is associated with high mortality rates and resistance to multiple classes of antifungal drugs and is difficult to identify with standard laboratory me...

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Autores principales: Mohsin, Jalila, Weerakoon, Sanjeewani, Ahmed, Sarah, Puts, Ynze, Al Balushi, Zainab, Meis, Jacques F., Al-Hatmi, Abdullah M.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598619/
https://www.ncbi.nlm.nih.gov/pubmed/32987692
http://dx.doi.org/10.3390/antibiotics9100638
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author Mohsin, Jalila
Weerakoon, Sanjeewani
Ahmed, Sarah
Puts, Ynze
Al Balushi, Zainab
Meis, Jacques F.
Al-Hatmi, Abdullah M.S.
author_facet Mohsin, Jalila
Weerakoon, Sanjeewani
Ahmed, Sarah
Puts, Ynze
Al Balushi, Zainab
Meis, Jacques F.
Al-Hatmi, Abdullah M.S.
author_sort Mohsin, Jalila
collection PubMed
description (1) Background: Candida auris has been reported as emerging yeast pathogen that can cause invasive bloodstream infections in healthcare settings. It is associated with high mortality rates and resistance to multiple classes of antifungal drugs and is difficult to identify with standard laboratory methods. (2) Methods: We conducted a retrospective review of epidemiological, clinical, and microbiological records for 23 C. auris fungemia cases at the Royal Hospital, a tertiary care facility in Oman, between 2016 and 2018. Demographic data, risk factors associated with mortality, microbiology investigation and treatment regimens are described. Yeasts were identified by MALDI-TOF. (3) Results: We identified 23 patients with C. auris fungemia. All positive samples from patients were confirmed as C. auris using MALDI-TOF, and ITS-rDNA sequencing. Microsatellite genotyping showed that the Omani isolates belong to the South Asian clade I. The majority of patients had multiple underlying illnesses and other risk factors that have been associated with fungemia. All isolates were non-susceptible to fluconazole. Isolates from all patients were sensitive to echinocandins and these were used as first line therapy. (4) Conclusions: Candida auris affects adults and children with a variety of risk factors including central venous catheters and overuse of antibiotics. Infections occur in both immunocompromised and immunocompetent individuals. Mortality was high in this series, and the organism can be transmitted in healthcare settings. Programs for raising awareness in Oman hospitals are warranted. Caspofungin remains 1st line therapy as MICs are still low despite its wide use.
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spelling pubmed-75986192020-10-31 A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019 Mohsin, Jalila Weerakoon, Sanjeewani Ahmed, Sarah Puts, Ynze Al Balushi, Zainab Meis, Jacques F. Al-Hatmi, Abdullah M.S. Antibiotics (Basel) Article (1) Background: Candida auris has been reported as emerging yeast pathogen that can cause invasive bloodstream infections in healthcare settings. It is associated with high mortality rates and resistance to multiple classes of antifungal drugs and is difficult to identify with standard laboratory methods. (2) Methods: We conducted a retrospective review of epidemiological, clinical, and microbiological records for 23 C. auris fungemia cases at the Royal Hospital, a tertiary care facility in Oman, between 2016 and 2018. Demographic data, risk factors associated with mortality, microbiology investigation and treatment regimens are described. Yeasts were identified by MALDI-TOF. (3) Results: We identified 23 patients with C. auris fungemia. All positive samples from patients were confirmed as C. auris using MALDI-TOF, and ITS-rDNA sequencing. Microsatellite genotyping showed that the Omani isolates belong to the South Asian clade I. The majority of patients had multiple underlying illnesses and other risk factors that have been associated with fungemia. All isolates were non-susceptible to fluconazole. Isolates from all patients were sensitive to echinocandins and these were used as first line therapy. (4) Conclusions: Candida auris affects adults and children with a variety of risk factors including central venous catheters and overuse of antibiotics. Infections occur in both immunocompromised and immunocompetent individuals. Mortality was high in this series, and the organism can be transmitted in healthcare settings. Programs for raising awareness in Oman hospitals are warranted. Caspofungin remains 1st line therapy as MICs are still low despite its wide use. MDPI 2020-09-24 /pmc/articles/PMC7598619/ /pubmed/32987692 http://dx.doi.org/10.3390/antibiotics9100638 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mohsin, Jalila
Weerakoon, Sanjeewani
Ahmed, Sarah
Puts, Ynze
Al Balushi, Zainab
Meis, Jacques F.
Al-Hatmi, Abdullah M.S.
A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title_full A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title_fullStr A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title_full_unstemmed A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title_short A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
title_sort cluster of candida auris blood stream infections in a tertiary care hospital in oman from 2016 to 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598619/
https://www.ncbi.nlm.nih.gov/pubmed/32987692
http://dx.doi.org/10.3390/antibiotics9100638
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