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Advances in Pulmonary Drug Delivery
Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598662/ https://www.ncbi.nlm.nih.gov/pubmed/32977672 http://dx.doi.org/10.3390/pharmaceutics12100911 |
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author | Yıldız-Peköz, Ayca Ehrhardt, Carsten |
author_facet | Yıldız-Peköz, Ayca Ehrhardt, Carsten |
author_sort | Yıldız-Peköz, Ayca |
collection | PubMed |
description | Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or via the lungs—in addition to the drug itself, its formulation into an appropriate inhalable dosage form of sufficient stability is critical. It is also essential that this formulation is paired with a suitable inhaler device, which generates an aerosol of a particle/droplet size that ensures deposition in the desired region of the respiratory tract. Lastly, the patient’s (patho-) physiology and inhalation manoeuvre are of importance. This Special Issue brings together recent advances in the areas of inhalation device testing, aerosol formulation development, use of in vitro and in silico models in pulmonary drug deposition and drug disposition studies, and pulmonary delivery of complex drugs, such as vaccines, antibiotics and peptides, to or via the lungs. |
format | Online Article Text |
id | pubmed-7598662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75986622020-10-31 Advances in Pulmonary Drug Delivery Yıldız-Peköz, Ayca Ehrhardt, Carsten Pharmaceutics Editorial Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or via the lungs—in addition to the drug itself, its formulation into an appropriate inhalable dosage form of sufficient stability is critical. It is also essential that this formulation is paired with a suitable inhaler device, which generates an aerosol of a particle/droplet size that ensures deposition in the desired region of the respiratory tract. Lastly, the patient’s (patho-) physiology and inhalation manoeuvre are of importance. This Special Issue brings together recent advances in the areas of inhalation device testing, aerosol formulation development, use of in vitro and in silico models in pulmonary drug deposition and drug disposition studies, and pulmonary delivery of complex drugs, such as vaccines, antibiotics and peptides, to or via the lungs. MDPI 2020-09-23 /pmc/articles/PMC7598662/ /pubmed/32977672 http://dx.doi.org/10.3390/pharmaceutics12100911 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Yıldız-Peköz, Ayca Ehrhardt, Carsten Advances in Pulmonary Drug Delivery |
title | Advances in Pulmonary Drug Delivery |
title_full | Advances in Pulmonary Drug Delivery |
title_fullStr | Advances in Pulmonary Drug Delivery |
title_full_unstemmed | Advances in Pulmonary Drug Delivery |
title_short | Advances in Pulmonary Drug Delivery |
title_sort | advances in pulmonary drug delivery |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598662/ https://www.ncbi.nlm.nih.gov/pubmed/32977672 http://dx.doi.org/10.3390/pharmaceutics12100911 |
work_keys_str_mv | AT yıldızpekozayca advancesinpulmonarydrugdelivery AT ehrhardtcarsten advancesinpulmonarydrugdelivery |