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Advances in Pulmonary Drug Delivery

Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or...

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Detalles Bibliográficos
Autores principales: Yıldız-Peköz, Ayca, Ehrhardt, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598662/
https://www.ncbi.nlm.nih.gov/pubmed/32977672
http://dx.doi.org/10.3390/pharmaceutics12100911
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author Yıldız-Peköz, Ayca
Ehrhardt, Carsten
author_facet Yıldız-Peköz, Ayca
Ehrhardt, Carsten
author_sort Yıldız-Peköz, Ayca
collection PubMed
description Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or via the lungs—in addition to the drug itself, its formulation into an appropriate inhalable dosage form of sufficient stability is critical. It is also essential that this formulation is paired with a suitable inhaler device, which generates an aerosol of a particle/droplet size that ensures deposition in the desired region of the respiratory tract. Lastly, the patient’s (patho-) physiology and inhalation manoeuvre are of importance. This Special Issue brings together recent advances in the areas of inhalation device testing, aerosol formulation development, use of in vitro and in silico models in pulmonary drug deposition and drug disposition studies, and pulmonary delivery of complex drugs, such as vaccines, antibiotics and peptides, to or via the lungs.
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spelling pubmed-75986622020-10-31 Advances in Pulmonary Drug Delivery Yıldız-Peköz, Ayca Ehrhardt, Carsten Pharmaceutics Editorial Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or via the lungs—in addition to the drug itself, its formulation into an appropriate inhalable dosage form of sufficient stability is critical. It is also essential that this formulation is paired with a suitable inhaler device, which generates an aerosol of a particle/droplet size that ensures deposition in the desired region of the respiratory tract. Lastly, the patient’s (patho-) physiology and inhalation manoeuvre are of importance. This Special Issue brings together recent advances in the areas of inhalation device testing, aerosol formulation development, use of in vitro and in silico models in pulmonary drug deposition and drug disposition studies, and pulmonary delivery of complex drugs, such as vaccines, antibiotics and peptides, to or via the lungs. MDPI 2020-09-23 /pmc/articles/PMC7598662/ /pubmed/32977672 http://dx.doi.org/10.3390/pharmaceutics12100911 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Yıldız-Peköz, Ayca
Ehrhardt, Carsten
Advances in Pulmonary Drug Delivery
title Advances in Pulmonary Drug Delivery
title_full Advances in Pulmonary Drug Delivery
title_fullStr Advances in Pulmonary Drug Delivery
title_full_unstemmed Advances in Pulmonary Drug Delivery
title_short Advances in Pulmonary Drug Delivery
title_sort advances in pulmonary drug delivery
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598662/
https://www.ncbi.nlm.nih.gov/pubmed/32977672
http://dx.doi.org/10.3390/pharmaceutics12100911
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