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Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report
RATIONALE: Extramedullary invasion of chronic myelomonocytic leukemia (CMML) usually occurs in the liver, spleen, and lymph nodes, while the pleural infiltration of CMML is rare. The presence of pleural effusion is usually associated with uncontrolled leukocytosis and increased monocytes. PATIENT CO...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598868/ https://www.ncbi.nlm.nih.gov/pubmed/33126392 http://dx.doi.org/10.1097/MD.0000000000023030 |
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author | Hu, Lianbo Zheng, Bingrong Fu, Lijuan Hu, Meiwei |
author_facet | Hu, Lianbo Zheng, Bingrong Fu, Lijuan Hu, Meiwei |
author_sort | Hu, Lianbo |
collection | PubMed |
description | RATIONALE: Extramedullary invasion of chronic myelomonocytic leukemia (CMML) usually occurs in the liver, spleen, and lymph nodes, while the pleural infiltration of CMML is rare. The presence of pleural effusion is usually associated with uncontrolled leukocytosis and increased monocytes. PATIENT CONCERNS: Here we reported a rare case of CMML-0 with pleural effusion as the first manifestation in a 44-year-old woman. The pleural effusion was caused by blasts infiltration confirmed by the flow cytometer and the pleural biopsy. DIAGNOSES: CMML with pleural invasion. INTERVENTIONS: The patient was treated with azacitidine 75 mg/m(2) d for 2 cycles, followed by daily oral intake of hydroxyurea (500 mg/d). OUTCOMES: Pleural effusion was resolved and chest pain was relieved. LESSONS: The current case indicated that leukemic infiltration into pleura could occur despite mild leukocytes, while demethylation may be an effective therapy. |
format | Online Article Text |
id | pubmed-7598868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75988682020-11-02 Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report Hu, Lianbo Zheng, Bingrong Fu, Lijuan Hu, Meiwei Medicine (Baltimore) 4800 RATIONALE: Extramedullary invasion of chronic myelomonocytic leukemia (CMML) usually occurs in the liver, spleen, and lymph nodes, while the pleural infiltration of CMML is rare. The presence of pleural effusion is usually associated with uncontrolled leukocytosis and increased monocytes. PATIENT CONCERNS: Here we reported a rare case of CMML-0 with pleural effusion as the first manifestation in a 44-year-old woman. The pleural effusion was caused by blasts infiltration confirmed by the flow cytometer and the pleural biopsy. DIAGNOSES: CMML with pleural invasion. INTERVENTIONS: The patient was treated with azacitidine 75 mg/m(2) d for 2 cycles, followed by daily oral intake of hydroxyurea (500 mg/d). OUTCOMES: Pleural effusion was resolved and chest pain was relieved. LESSONS: The current case indicated that leukemic infiltration into pleura could occur despite mild leukocytes, while demethylation may be an effective therapy. Lippincott Williams & Wilkins 2020-10-30 /pmc/articles/PMC7598868/ /pubmed/33126392 http://dx.doi.org/10.1097/MD.0000000000023030 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4800 Hu, Lianbo Zheng, Bingrong Fu, Lijuan Hu, Meiwei Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title | Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title_full | Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title_fullStr | Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title_full_unstemmed | Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title_short | Chronic myelomonocytic leukemia (CMML)-0 with pleural effusion as first manifestation: A case report |
title_sort | chronic myelomonocytic leukemia (cmml)-0 with pleural effusion as first manifestation: a case report |
topic | 4800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598868/ https://www.ncbi.nlm.nih.gov/pubmed/33126392 http://dx.doi.org/10.1097/MD.0000000000023030 |
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