Cargando…

Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa

Visceral Leishmaniasis (VL) due to Leishmania donovani is a neglected protozoan parasitic disease in humans, which is usually fatal if untreated. Phlebotomus orientalis, the predominant VL vector in East Africa, is a highly exophilic/exophagic species that poses a major challenge to current Integrat...

Descripción completa

Detalles Bibliográficos
Autores principales: Elnaiem, Dia-Eldin A., Dakein, Osman, Alawad, Ahmed Mohammed-Ali, Alsharif, Bashir, Khogali, Altayeb, Jibreel, Tayseer, Osman, Omran F., Has’san, Hassan, Atia, Atia Mohamed, Elhag, Mousab, Den Boer, Margriet, Ritmeijer, Koert, Bern, Caryn, Alvar, Jorge, Khalid, Noteila, Courtenay, Orin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598920/
https://www.ncbi.nlm.nih.gov/pubmed/33079934
http://dx.doi.org/10.1371/journal.pntd.0008774
_version_ 1783602750760681472
author Elnaiem, Dia-Eldin A.
Dakein, Osman
Alawad, Ahmed Mohammed-Ali
Alsharif, Bashir
Khogali, Altayeb
Jibreel, Tayseer
Osman, Omran F.
Has’san, Hassan
Atia, Atia Mohamed
Elhag, Mousab
Den Boer, Margriet
Ritmeijer, Koert
Bern, Caryn
Alvar, Jorge
Khalid, Noteila
Courtenay, Orin
author_facet Elnaiem, Dia-Eldin A.
Dakein, Osman
Alawad, Ahmed Mohammed-Ali
Alsharif, Bashir
Khogali, Altayeb
Jibreel, Tayseer
Osman, Omran F.
Has’san, Hassan
Atia, Atia Mohamed
Elhag, Mousab
Den Boer, Margriet
Ritmeijer, Koert
Bern, Caryn
Alvar, Jorge
Khalid, Noteila
Courtenay, Orin
author_sort Elnaiem, Dia-Eldin A.
collection PubMed
description Visceral Leishmaniasis (VL) due to Leishmania donovani is a neglected protozoan parasitic disease in humans, which is usually fatal if untreated. Phlebotomus orientalis, the predominant VL vector in East Africa, is a highly exophilic/exophagic species that poses a major challenge to current Integrated Vector Management (IVM). Here we report results of pilot studies conducted in rural villages in Gedarif state, Sudan, to evaluate outdoor residual spraying of 20mg active ingredient (a.i.) /m(2) deltamethrin insecticide applied to the characteristic household compound boundary reed fence and to the outside of household buildings (Outdoor Residual Insecticide Spraying, ODRS), and as an alternative, spraying restricted to the boundary fence only (Restricted Outdoor Residual Insecticide Spraying, RODRS). Four to six clusters of 20 households were assigned to insecticide treatments or control in three experiments. Changes in sand fly numbers were monitored over 2,033 trap-nights over 43–76 days follow-up in four sentinel houses per cluster relative to unsprayed control clusters. Sand fly numbers were monitored by sticky traps placed on the ground on the inside (“outdoor”) and the outside (“peridomestic”) of the boundary fence, and by CDC light traps suspended outdoors in the household compound. The effects of ODRS on sand fly numbers inside sleeping huts were monitored by insecticide knockdown. After a single application, ODRS reduced P. orientalis abundance by 83%-99% in outdoor and peridomestic trap locations. ODRS also reduced numbers of P. orientalis found resting inside sleeping huts. RODRS reduced outdoor and peridomestic P. orientalis by 60%-88%. By direct comparison, RODRS was 58%-100% as effective as ODRS depending on the trapping method. These impacts were immediate on intervention and persisted during follow-up, representing a large fraction of the P. orientalis activity season. Relative costs of ODRS and RODRS delivery were $5.76 and $3.48 per household, respectively. The study demonstrates the feasibility and high entomological efficacy of ODRS and RODRS, and the expected low costs relative to current IVM practises. These methods represent novel sand fly vector control tools against predominantly exophilic/exophagic sand fly vectors, aimed to lower VL burdens in Sudan, with potential application in other endemic regions in East Africa.
format Online
Article
Text
id pubmed-7598920
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-75989202020-11-03 Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa Elnaiem, Dia-Eldin A. Dakein, Osman Alawad, Ahmed Mohammed-Ali Alsharif, Bashir Khogali, Altayeb Jibreel, Tayseer Osman, Omran F. Has’san, Hassan Atia, Atia Mohamed Elhag, Mousab Den Boer, Margriet Ritmeijer, Koert Bern, Caryn Alvar, Jorge Khalid, Noteila Courtenay, Orin PLoS Negl Trop Dis Research Article Visceral Leishmaniasis (VL) due to Leishmania donovani is a neglected protozoan parasitic disease in humans, which is usually fatal if untreated. Phlebotomus orientalis, the predominant VL vector in East Africa, is a highly exophilic/exophagic species that poses a major challenge to current Integrated Vector Management (IVM). Here we report results of pilot studies conducted in rural villages in Gedarif state, Sudan, to evaluate outdoor residual spraying of 20mg active ingredient (a.i.) /m(2) deltamethrin insecticide applied to the characteristic household compound boundary reed fence and to the outside of household buildings (Outdoor Residual Insecticide Spraying, ODRS), and as an alternative, spraying restricted to the boundary fence only (Restricted Outdoor Residual Insecticide Spraying, RODRS). Four to six clusters of 20 households were assigned to insecticide treatments or control in three experiments. Changes in sand fly numbers were monitored over 2,033 trap-nights over 43–76 days follow-up in four sentinel houses per cluster relative to unsprayed control clusters. Sand fly numbers were monitored by sticky traps placed on the ground on the inside (“outdoor”) and the outside (“peridomestic”) of the boundary fence, and by CDC light traps suspended outdoors in the household compound. The effects of ODRS on sand fly numbers inside sleeping huts were monitored by insecticide knockdown. After a single application, ODRS reduced P. orientalis abundance by 83%-99% in outdoor and peridomestic trap locations. ODRS also reduced numbers of P. orientalis found resting inside sleeping huts. RODRS reduced outdoor and peridomestic P. orientalis by 60%-88%. By direct comparison, RODRS was 58%-100% as effective as ODRS depending on the trapping method. These impacts were immediate on intervention and persisted during follow-up, representing a large fraction of the P. orientalis activity season. Relative costs of ODRS and RODRS delivery were $5.76 and $3.48 per household, respectively. The study demonstrates the feasibility and high entomological efficacy of ODRS and RODRS, and the expected low costs relative to current IVM practises. These methods represent novel sand fly vector control tools against predominantly exophilic/exophagic sand fly vectors, aimed to lower VL burdens in Sudan, with potential application in other endemic regions in East Africa. Public Library of Science 2020-10-20 /pmc/articles/PMC7598920/ /pubmed/33079934 http://dx.doi.org/10.1371/journal.pntd.0008774 Text en © 2020 Elnaiem et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Elnaiem, Dia-Eldin A.
Dakein, Osman
Alawad, Ahmed Mohammed-Ali
Alsharif, Bashir
Khogali, Altayeb
Jibreel, Tayseer
Osman, Omran F.
Has’san, Hassan
Atia, Atia Mohamed
Elhag, Mousab
Den Boer, Margriet
Ritmeijer, Koert
Bern, Caryn
Alvar, Jorge
Khalid, Noteila
Courtenay, Orin
Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title_full Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title_fullStr Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title_full_unstemmed Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title_short Outdoor Residual Insecticide Spraying (ODRS), a New Approach for the Control of the Exophilic Vectors of Human Visceral Leishmaniasis: Phlebotomus orientalis in East Africa
title_sort outdoor residual insecticide spraying (odrs), a new approach for the control of the exophilic vectors of human visceral leishmaniasis: phlebotomus orientalis in east africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598920/
https://www.ncbi.nlm.nih.gov/pubmed/33079934
http://dx.doi.org/10.1371/journal.pntd.0008774
work_keys_str_mv AT elnaiemdiaeldina outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT dakeinosman outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT alawadahmedmohammedali outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT alsharifbashir outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT khogalialtayeb outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT jibreeltayseer outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT osmanomranf outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT hassanhassan outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT atiaatiamohamed outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT elhagmousab outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT denboermargriet outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT ritmeijerkoert outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT berncaryn outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT alvarjorge outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT khalidnoteila outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica
AT courtenayorin outdoorresidualinsecticidesprayingodrsanewapproachforthecontroloftheexophilicvectorsofhumanvisceralleishmaniasisphlebotomusorientalisineastafrica