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Investigation of AKI with Early Biomarkers After Cardiac Surgery

OBJECTIVE: To provide a new interpretation of the effect of intraoperative hemodynamic data on postoperative acute kidney injury (AKI) development and to determine the accuracy of some biomarkers which are thought to be the early markers of renal injury. METHODS: One hundred adult patients who were...

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Autores principales: Mutlu, Hüseyin, Gündüz, Emel, Titiz, Tülin Aydoğdu, Küçükçetin, İkbal Özen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598966/
https://www.ncbi.nlm.nih.gov/pubmed/33118738
http://dx.doi.org/10.21470/1678-9741-2019-0178
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author Mutlu, Hüseyin
Gündüz, Emel
Titiz, Tülin Aydoğdu
Küçükçetin, İkbal Özen
author_facet Mutlu, Hüseyin
Gündüz, Emel
Titiz, Tülin Aydoğdu
Küçükçetin, İkbal Özen
author_sort Mutlu, Hüseyin
collection PubMed
description OBJECTIVE: To provide a new interpretation of the effect of intraoperative hemodynamic data on postoperative acute kidney injury (AKI) development and to determine the accuracy of some biomarkers which are thought to be the early markers of renal injury. METHODS: One hundred adult patients who were connected to the heart-lung pump during open-heart surgery were included in this study. Hemodynamic data, oxygen delivery, and transfusions were recorded intraoperatively, and the preoperative and 3. postoperative hour cystatin C, interleukin-18 (IL-18), and neutrophil gelatinase-associated lipocalin (NGAL) parameters were measured for early detection of kidney damage. In the analysis, 95% significance level was used to determine the difference. RESULTS: According to the Kidney Disease Improving Global Outcomes criterion, AKI developed in 24 patients, 18 of whom were stage 1, two were stage 2, and four were stage 3. AKI (+) patients had more transfusions in the intraoperative period and AKI development was a risk factor for postoperative complications. NGAL and IL-18 levels were found to be approximately two-fold in the postoperative period in AKI (+) patients, whereas cystatin C was not sensitive in AKI detection. CONCLUSION: AKI development increases the risk of postoperative complications. NGAL and IL-18 were successful in detecting AKI in the early postoperative period.
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spelling pubmed-75989662020-11-04 Investigation of AKI with Early Biomarkers After Cardiac Surgery Mutlu, Hüseyin Gündüz, Emel Titiz, Tülin Aydoğdu Küçükçetin, İkbal Özen Braz J Cardiovasc Surg Original Article OBJECTIVE: To provide a new interpretation of the effect of intraoperative hemodynamic data on postoperative acute kidney injury (AKI) development and to determine the accuracy of some biomarkers which are thought to be the early markers of renal injury. METHODS: One hundred adult patients who were connected to the heart-lung pump during open-heart surgery were included in this study. Hemodynamic data, oxygen delivery, and transfusions were recorded intraoperatively, and the preoperative and 3. postoperative hour cystatin C, interleukin-18 (IL-18), and neutrophil gelatinase-associated lipocalin (NGAL) parameters were measured for early detection of kidney damage. In the analysis, 95% significance level was used to determine the difference. RESULTS: According to the Kidney Disease Improving Global Outcomes criterion, AKI developed in 24 patients, 18 of whom were stage 1, two were stage 2, and four were stage 3. AKI (+) patients had more transfusions in the intraoperative period and AKI development was a risk factor for postoperative complications. NGAL and IL-18 levels were found to be approximately two-fold in the postoperative period in AKI (+) patients, whereas cystatin C was not sensitive in AKI detection. CONCLUSION: AKI development increases the risk of postoperative complications. NGAL and IL-18 were successful in detecting AKI in the early postoperative period. Sociedade Brasileira de Cirurgia Cardiovascular 2020 /pmc/articles/PMC7598966/ /pubmed/33118738 http://dx.doi.org/10.21470/1678-9741-2019-0178 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mutlu, Hüseyin
Gündüz, Emel
Titiz, Tülin Aydoğdu
Küçükçetin, İkbal Özen
Investigation of AKI with Early Biomarkers After Cardiac Surgery
title Investigation of AKI with Early Biomarkers After Cardiac Surgery
title_full Investigation of AKI with Early Biomarkers After Cardiac Surgery
title_fullStr Investigation of AKI with Early Biomarkers After Cardiac Surgery
title_full_unstemmed Investigation of AKI with Early Biomarkers After Cardiac Surgery
title_short Investigation of AKI with Early Biomarkers After Cardiac Surgery
title_sort investigation of aki with early biomarkers after cardiac surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598966/
https://www.ncbi.nlm.nih.gov/pubmed/33118738
http://dx.doi.org/10.21470/1678-9741-2019-0178
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