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Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging

In this work we propose an index to estimate the gut microbiota biodiversity using a modeling approach with the aim of describing its relationship with health and aging. The gut microbiota, a complex ecosystem that links nutrition and metabolism, has a pervasive effect on all body organs and systems...

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Autores principales: Sala, Claudia, Giampieri, Enrico, Vitali, Silvia, Garagnani, Paolo, Remondini, Daniel, Bazzani, Armando, Franceschi, Claudio, Castellani, Gastone C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599046/
https://www.ncbi.nlm.nih.gov/pubmed/33125392
http://dx.doi.org/10.1371/journal.pone.0237207
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author Sala, Claudia
Giampieri, Enrico
Vitali, Silvia
Garagnani, Paolo
Remondini, Daniel
Bazzani, Armando
Franceschi, Claudio
Castellani, Gastone C.
author_facet Sala, Claudia
Giampieri, Enrico
Vitali, Silvia
Garagnani, Paolo
Remondini, Daniel
Bazzani, Armando
Franceschi, Claudio
Castellani, Gastone C.
author_sort Sala, Claudia
collection PubMed
description In this work we propose an index to estimate the gut microbiota biodiversity using a modeling approach with the aim of describing its relationship with health and aging. The gut microbiota, a complex ecosystem that links nutrition and metabolism, has a pervasive effect on all body organs and systems, undergoes profound changes with age and life-style, and substantially contributes to the pathogenesis of age-related diseases. For these reasons, the gut microbiota is a suitable candidate for assessing and quantifying healthy aging, i.e. the capability of individuals to reach an advanced age, avoiding or postponing major age-related diseases. The importance of the gut microbiota in health and aging has been proven to be related not only to its taxonomic composition, but also to its ecological properties, namely its biodiversity. Following an ecological approach, here we intended to characterize the relationship between the gut microbiota biodiversity and healthy aging through the development a parsimonious model of gut microbiota from which biodiversity can be estimated. We analysed publicly available metagenomic data relative to subjects of different ages, countries, nutritional habits and health status and we showed that a hybrid niche-neutral model well describes the observed patterns of bacterial relative abundance. Moreover, starting from such ecological modeling, we derived an estimate of the gut microbiota biodiversity that is consistent with classical indices, while having a higher statistical power. This allowed us to unveil an increase of the gut microbiota biodiversity during aging and to provide a good predictor of health status in old age, dependent on life-style and aging disorders.
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spelling pubmed-75990462020-11-03 Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging Sala, Claudia Giampieri, Enrico Vitali, Silvia Garagnani, Paolo Remondini, Daniel Bazzani, Armando Franceschi, Claudio Castellani, Gastone C. PLoS One Research Article In this work we propose an index to estimate the gut microbiota biodiversity using a modeling approach with the aim of describing its relationship with health and aging. The gut microbiota, a complex ecosystem that links nutrition and metabolism, has a pervasive effect on all body organs and systems, undergoes profound changes with age and life-style, and substantially contributes to the pathogenesis of age-related diseases. For these reasons, the gut microbiota is a suitable candidate for assessing and quantifying healthy aging, i.e. the capability of individuals to reach an advanced age, avoiding or postponing major age-related diseases. The importance of the gut microbiota in health and aging has been proven to be related not only to its taxonomic composition, but also to its ecological properties, namely its biodiversity. Following an ecological approach, here we intended to characterize the relationship between the gut microbiota biodiversity and healthy aging through the development a parsimonious model of gut microbiota from which biodiversity can be estimated. We analysed publicly available metagenomic data relative to subjects of different ages, countries, nutritional habits and health status and we showed that a hybrid niche-neutral model well describes the observed patterns of bacterial relative abundance. Moreover, starting from such ecological modeling, we derived an estimate of the gut microbiota biodiversity that is consistent with classical indices, while having a higher statistical power. This allowed us to unveil an increase of the gut microbiota biodiversity during aging and to provide a good predictor of health status in old age, dependent on life-style and aging disorders. Public Library of Science 2020-10-30 /pmc/articles/PMC7599046/ /pubmed/33125392 http://dx.doi.org/10.1371/journal.pone.0237207 Text en © 2020 Sala et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sala, Claudia
Giampieri, Enrico
Vitali, Silvia
Garagnani, Paolo
Remondini, Daniel
Bazzani, Armando
Franceschi, Claudio
Castellani, Gastone C.
Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title_full Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title_fullStr Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title_full_unstemmed Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title_short Gut microbiota ecology: Biodiversity estimated from hybrid neutral-niche model increases with health status and aging
title_sort gut microbiota ecology: biodiversity estimated from hybrid neutral-niche model increases with health status and aging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599046/
https://www.ncbi.nlm.nih.gov/pubmed/33125392
http://dx.doi.org/10.1371/journal.pone.0237207
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