Cargando…

Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia

Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by recurrent multiple motor and vocal tics that last for at least one year and follow a waxing and waning course. A fundamental step in the pathophysiology of TS is the hyperactivity of dopaminergic system leading to increas...

Descripción completa

Detalles Bibliográficos
Autores principales: Maqsood, Anum, Akram, Salman, Akram, Faisal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599051/
https://www.ncbi.nlm.nih.gov/pubmed/33145137
http://dx.doi.org/10.7759/cureus.10732
_version_ 1783602783391318016
author Maqsood, Anum
Akram, Salman
Akram, Faisal
author_facet Maqsood, Anum
Akram, Salman
Akram, Faisal
author_sort Maqsood, Anum
collection PubMed
description Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by recurrent multiple motor and vocal tics that last for at least one year and follow a waxing and waning course. A fundamental step in the pathophysiology of TS is the hyperactivity of dopaminergic system leading to increased dopamine release in the cortical-basal ganglia-thalamo-cortical (CBGTC) circuits, thereby providing the rationale for treatment with dopamine receptor, in particular D2, antagonists. Although antipsychotics have shown considerable efficacy against tics in most patients, there have been cases of paradoxical onset of tics in individuals without history, and relapse or exacerbation of tics in individuals with a history of tic disorders upon initiation of antipsychotics. Here we report a case of an individual with intellectual disability, attention deficit hyperactivity disorder (ADHD), and schizophrenia, who experienced a relapse of TS symptoms after initiation of chlorpromazine therapy.
format Online
Article
Text
id pubmed-7599051
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-75990512020-11-02 Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia Maqsood, Anum Akram, Salman Akram, Faisal Cureus Neurology Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by recurrent multiple motor and vocal tics that last for at least one year and follow a waxing and waning course. A fundamental step in the pathophysiology of TS is the hyperactivity of dopaminergic system leading to increased dopamine release in the cortical-basal ganglia-thalamo-cortical (CBGTC) circuits, thereby providing the rationale for treatment with dopamine receptor, in particular D2, antagonists. Although antipsychotics have shown considerable efficacy against tics in most patients, there have been cases of paradoxical onset of tics in individuals without history, and relapse or exacerbation of tics in individuals with a history of tic disorders upon initiation of antipsychotics. Here we report a case of an individual with intellectual disability, attention deficit hyperactivity disorder (ADHD), and schizophrenia, who experienced a relapse of TS symptoms after initiation of chlorpromazine therapy. Cureus 2020-09-30 /pmc/articles/PMC7599051/ /pubmed/33145137 http://dx.doi.org/10.7759/cureus.10732 Text en Copyright © 2020, Maqsood et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Maqsood, Anum
Akram, Salman
Akram, Faisal
Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title_full Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title_fullStr Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title_full_unstemmed Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title_short Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia
title_sort chlorpromazine-induced relapse of tourette syndrome in a patient with intellectual disability, attention deficit hyperactivity disorder, and schizophrenia
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599051/
https://www.ncbi.nlm.nih.gov/pubmed/33145137
http://dx.doi.org/10.7759/cureus.10732
work_keys_str_mv AT maqsoodanum chlorpromazineinducedrelapseoftourettesyndromeinapatientwithintellectualdisabilityattentiondeficithyperactivitydisorderandschizophrenia
AT akramsalman chlorpromazineinducedrelapseoftourettesyndromeinapatientwithintellectualdisabilityattentiondeficithyperactivitydisorderandschizophrenia
AT akramfaisal chlorpromazineinducedrelapseoftourettesyndromeinapatientwithintellectualdisabilityattentiondeficithyperactivitydisorderandschizophrenia