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Central Nervous System Manifestations Associated with COVID-19
PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 ha...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599061/ https://www.ncbi.nlm.nih.gov/pubmed/33128130 http://dx.doi.org/10.1007/s11910-020-01079-7 |
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author | Divani, Afshin A. Andalib, Sasan Biller, José Di Napoli, Mario Moghimi, Narges Rubinos, Clio A. Nobleza, Christa O’Hana Sylaja, P. N Toledano, Michel Lattanzi, Simona McCullough, Louise D Cruz-Flores, Salvador Torbey, Michel Azarpazhooh, M. Reza |
author_facet | Divani, Afshin A. Andalib, Sasan Biller, José Di Napoli, Mario Moghimi, Narges Rubinos, Clio A. Nobleza, Christa O’Hana Sylaja, P. N Toledano, Michel Lattanzi, Simona McCullough, Louise D Cruz-Flores, Salvador Torbey, Michel Azarpazhooh, M. Reza |
author_sort | Divani, Afshin A. |
collection | PubMed |
description | PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations. RECENT FINDINGS: A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19. SUMMARY: CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms. |
format | Online Article Text |
id | pubmed-7599061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-75990612020-11-02 Central Nervous System Manifestations Associated with COVID-19 Divani, Afshin A. Andalib, Sasan Biller, José Di Napoli, Mario Moghimi, Narges Rubinos, Clio A. Nobleza, Christa O’Hana Sylaja, P. N Toledano, Michel Lattanzi, Simona McCullough, Louise D Cruz-Flores, Salvador Torbey, Michel Azarpazhooh, M. Reza Curr Neurol Neurosci Rep Neurology of Systemic Disease (J Biller, Section Editor) PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations. RECENT FINDINGS: A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19. SUMMARY: CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms. Springer US 2020-10-30 2020 /pmc/articles/PMC7599061/ /pubmed/33128130 http://dx.doi.org/10.1007/s11910-020-01079-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Neurology of Systemic Disease (J Biller, Section Editor) Divani, Afshin A. Andalib, Sasan Biller, José Di Napoli, Mario Moghimi, Narges Rubinos, Clio A. Nobleza, Christa O’Hana Sylaja, P. N Toledano, Michel Lattanzi, Simona McCullough, Louise D Cruz-Flores, Salvador Torbey, Michel Azarpazhooh, M. Reza Central Nervous System Manifestations Associated with COVID-19 |
title | Central Nervous System Manifestations Associated with COVID-19 |
title_full | Central Nervous System Manifestations Associated with COVID-19 |
title_fullStr | Central Nervous System Manifestations Associated with COVID-19 |
title_full_unstemmed | Central Nervous System Manifestations Associated with COVID-19 |
title_short | Central Nervous System Manifestations Associated with COVID-19 |
title_sort | central nervous system manifestations associated with covid-19 |
topic | Neurology of Systemic Disease (J Biller, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599061/ https://www.ncbi.nlm.nih.gov/pubmed/33128130 http://dx.doi.org/10.1007/s11910-020-01079-7 |
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