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Central Nervous System Manifestations Associated with COVID-19

PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 ha...

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Autores principales: Divani, Afshin A., Andalib, Sasan, Biller, José, Di Napoli, Mario, Moghimi, Narges, Rubinos, Clio A., Nobleza, Christa O’Hana, Sylaja, P. N, Toledano, Michel, Lattanzi, Simona, McCullough, Louise D, Cruz-Flores, Salvador, Torbey, Michel, Azarpazhooh, M. Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599061/
https://www.ncbi.nlm.nih.gov/pubmed/33128130
http://dx.doi.org/10.1007/s11910-020-01079-7
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author Divani, Afshin A.
Andalib, Sasan
Biller, José
Di Napoli, Mario
Moghimi, Narges
Rubinos, Clio A.
Nobleza, Christa O’Hana
Sylaja, P. N
Toledano, Michel
Lattanzi, Simona
McCullough, Louise D
Cruz-Flores, Salvador
Torbey, Michel
Azarpazhooh, M. Reza
author_facet Divani, Afshin A.
Andalib, Sasan
Biller, José
Di Napoli, Mario
Moghimi, Narges
Rubinos, Clio A.
Nobleza, Christa O’Hana
Sylaja, P. N
Toledano, Michel
Lattanzi, Simona
McCullough, Louise D
Cruz-Flores, Salvador
Torbey, Michel
Azarpazhooh, M. Reza
author_sort Divani, Afshin A.
collection PubMed
description PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations. RECENT FINDINGS: A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19. SUMMARY: CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms.
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spelling pubmed-75990612020-11-02 Central Nervous System Manifestations Associated with COVID-19 Divani, Afshin A. Andalib, Sasan Biller, José Di Napoli, Mario Moghimi, Narges Rubinos, Clio A. Nobleza, Christa O’Hana Sylaja, P. N Toledano, Michel Lattanzi, Simona McCullough, Louise D Cruz-Flores, Salvador Torbey, Michel Azarpazhooh, M. Reza Curr Neurol Neurosci Rep Neurology of Systemic Disease (J Biller, Section Editor) PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations. RECENT FINDINGS: A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19. SUMMARY: CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms. Springer US 2020-10-30 2020 /pmc/articles/PMC7599061/ /pubmed/33128130 http://dx.doi.org/10.1007/s11910-020-01079-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Neurology of Systemic Disease (J Biller, Section Editor)
Divani, Afshin A.
Andalib, Sasan
Biller, José
Di Napoli, Mario
Moghimi, Narges
Rubinos, Clio A.
Nobleza, Christa O’Hana
Sylaja, P. N
Toledano, Michel
Lattanzi, Simona
McCullough, Louise D
Cruz-Flores, Salvador
Torbey, Michel
Azarpazhooh, M. Reza
Central Nervous System Manifestations Associated with COVID-19
title Central Nervous System Manifestations Associated with COVID-19
title_full Central Nervous System Manifestations Associated with COVID-19
title_fullStr Central Nervous System Manifestations Associated with COVID-19
title_full_unstemmed Central Nervous System Manifestations Associated with COVID-19
title_short Central Nervous System Manifestations Associated with COVID-19
title_sort central nervous system manifestations associated with covid-19
topic Neurology of Systemic Disease (J Biller, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599061/
https://www.ncbi.nlm.nih.gov/pubmed/33128130
http://dx.doi.org/10.1007/s11910-020-01079-7
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