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Dopamine promotes instrumental motivation, but reduces reward-related vigour

We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich envir...

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Detalles Bibliográficos
Autores principales: Grogan, John P, Sandhu, Timothy R, Hu, Michele T, Manohar, Sanjay G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599069/
https://www.ncbi.nlm.nih.gov/pubmed/33001026
http://dx.doi.org/10.7554/eLife.58321
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author Grogan, John P
Sandhu, Timothy R
Hu, Michele T
Manohar, Sanjay G
author_facet Grogan, John P
Sandhu, Timothy R
Hu, Michele T
Manohar, Sanjay G
author_sort Grogan, John P
collection PubMed
description We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson’s disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for contingent rewards, whereas when PD patients were OFF medication, they had greater vigour for guaranteed rewards. These results support the view that reward expectation and contingency drive distinct motivational processes, and can be dissociated by manipulating dopaminergic activity. We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, contradictory to the prediction that increased tonic dopamine amplifies reward expectation.
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spelling pubmed-75990692020-11-02 Dopamine promotes instrumental motivation, but reduces reward-related vigour Grogan, John P Sandhu, Timothy R Hu, Michele T Manohar, Sanjay G eLife Neuroscience We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson’s disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for contingent rewards, whereas when PD patients were OFF medication, they had greater vigour for guaranteed rewards. These results support the view that reward expectation and contingency drive distinct motivational processes, and can be dissociated by manipulating dopaminergic activity. We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, contradictory to the prediction that increased tonic dopamine amplifies reward expectation. eLife Sciences Publications, Ltd 2020-10-01 /pmc/articles/PMC7599069/ /pubmed/33001026 http://dx.doi.org/10.7554/eLife.58321 Text en © 2020, Grogan et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Grogan, John P
Sandhu, Timothy R
Hu, Michele T
Manohar, Sanjay G
Dopamine promotes instrumental motivation, but reduces reward-related vigour
title Dopamine promotes instrumental motivation, but reduces reward-related vigour
title_full Dopamine promotes instrumental motivation, but reduces reward-related vigour
title_fullStr Dopamine promotes instrumental motivation, but reduces reward-related vigour
title_full_unstemmed Dopamine promotes instrumental motivation, but reduces reward-related vigour
title_short Dopamine promotes instrumental motivation, but reduces reward-related vigour
title_sort dopamine promotes instrumental motivation, but reduces reward-related vigour
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599069/
https://www.ncbi.nlm.nih.gov/pubmed/33001026
http://dx.doi.org/10.7554/eLife.58321
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