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Dopamine promotes instrumental motivation, but reduces reward-related vigour
We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich envir...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599069/ https://www.ncbi.nlm.nih.gov/pubmed/33001026 http://dx.doi.org/10.7554/eLife.58321 |
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author | Grogan, John P Sandhu, Timothy R Hu, Michele T Manohar, Sanjay G |
author_facet | Grogan, John P Sandhu, Timothy R Hu, Michele T Manohar, Sanjay G |
author_sort | Grogan, John P |
collection | PubMed |
description | We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson’s disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for contingent rewards, whereas when PD patients were OFF medication, they had greater vigour for guaranteed rewards. These results support the view that reward expectation and contingency drive distinct motivational processes, and can be dissociated by manipulating dopaminergic activity. We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, contradictory to the prediction that increased tonic dopamine amplifies reward expectation. |
format | Online Article Text |
id | pubmed-7599069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-75990692020-11-02 Dopamine promotes instrumental motivation, but reduces reward-related vigour Grogan, John P Sandhu, Timothy R Hu, Michele T Manohar, Sanjay G eLife Neuroscience We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson’s disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for contingent rewards, whereas when PD patients were OFF medication, they had greater vigour for guaranteed rewards. These results support the view that reward expectation and contingency drive distinct motivational processes, and can be dissociated by manipulating dopaminergic activity. We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, contradictory to the prediction that increased tonic dopamine amplifies reward expectation. eLife Sciences Publications, Ltd 2020-10-01 /pmc/articles/PMC7599069/ /pubmed/33001026 http://dx.doi.org/10.7554/eLife.58321 Text en © 2020, Grogan et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Grogan, John P Sandhu, Timothy R Hu, Michele T Manohar, Sanjay G Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title | Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title_full | Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title_fullStr | Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title_full_unstemmed | Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title_short | Dopamine promotes instrumental motivation, but reduces reward-related vigour |
title_sort | dopamine promotes instrumental motivation, but reduces reward-related vigour |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599069/ https://www.ncbi.nlm.nih.gov/pubmed/33001026 http://dx.doi.org/10.7554/eLife.58321 |
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