TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon (IFN) pathways. Here we show that this inflammation is drive...

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Detalles Bibliográficos
Autores principales: Yu, Chien-Hsiung, Davidson, Sophia, Harapas, Cassandra R., Hilton, James B., Mlodzianoski, Michael J., Laohamonthonkul, Pawat, Louis, Cynthia, Low, Ronnie Ren Jie, Moecking, Jonas, De Nardo, Dominic, Balka, Katherine R., Calleja, Dale J., Moghaddas, Fiona, Ni, Erya, McLean, Catriona A., Samson, Andre L., Tyebji, Shiraz, Tonkin, Christopher J., Bye, Christopher R., Turner, Bradley J., Pepin, Genevieve, Gantier, Michael P., Rogers, Kelly L., McArthur, Kate, Crouch, Peter J., Masters, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599077/
https://www.ncbi.nlm.nih.gov/pubmed/33031745
http://dx.doi.org/10.1016/j.cell.2020.09.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599077/
https://www.ncbi.nlm.nih.gov/pubmed/33031745
http://dx.doi.org/10.1016/j.cell.2020.09.020

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