YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer

BACKGROUND: N6-methyladenosine (m(6)A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m(6)A is comprehensively involved in various diseases especially cancers. As a crucial reader, YTHDF2 usually mediates the degradation of m(6)A-modified mRNAs in...

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Detalles Bibliográficos
Autores principales: Li, Jiangfeng, Xie, Haiyun, Ying, Yufan, Chen, Hong, Yan, Huaqing, He, Liujia, Xu, Mingjie, Xu, Xin, Liang, Zhen, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, Xie, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599101/
https://www.ncbi.nlm.nih.gov/pubmed/33121495
http://dx.doi.org/10.1186/s12943-020-01267-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599101/
https://www.ncbi.nlm.nih.gov/pubmed/33121495
http://dx.doi.org/10.1186/s12943-020-01267-6

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