Cargando…

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer

BACKGROUND: N6-methyladenosine (m(6)A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m(6)A is comprehensively involved in various diseases especially cancers. As a crucial reader, YTHDF2 usually mediates the degradation of m(6)A-modified mRNAs in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiangfeng, Xie, Haiyun, Ying, Yufan, Chen, Hong, Yan, Huaqing, He, Liujia, Xu, Mingjie, Xu, Xin, Liang, Zhen, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, Xie, Liping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599101/ https://www.ncbi.nlm.nih.gov/pubmed/33121495 http://dx.doi.org/10.1186/s12943-020-01267-6

Ejemplares similares

The dual role of N6‐methyladenosine modification of RNAs is involved in human cancers
por: He, Liujia, et al.
Publicado: (2018)

METTL3/YTHDF2 m(6)A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer
por: Xie, Haiyun, et al.
Publicado: (2020)

Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels
por: Li, Jiangfeng, et al.
Publicado: (2017)

Secondhand smoking increases bladder cancer risk in nonsmoking population: a meta-analysis
por: Yan, Huaqing, et al.
Publicado: (2018)

CCND1, NOP14 and DNMT3B are involved in miR‐502‐5p–mediated inhibition of cell migration and proliferation in bladder cancer
por: Ying, Yufan, et al.
Publicado: (2020)

Pioglitazone use in patients with diabetes and risk of bladder cancer: a systematic review and meta-analysis
por: Yan, Huaqing, et al.
Publicado: (2018)

Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
por: Wang, Xiao, et al.
Publicado: (2020)

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP
por: He, Liujia, et al.
Publicado: (2021)

Dysregulation of ncRNAs located at the DLK1‑DIO3 imprinted domain: involvement in urological cancers
por: Li, Jiangfeng, et al.
Publicado: (2019)

FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2
por: Xu, Fei, et al.
Publicado: (2021)

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
por: Li, Jiong, et al.
Publicado: (2021)

N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms
por: Chen, Lin, et al.
Publicado: (2023)

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
por: Ma, Xueyou, et al.
Publicado: (2021)

EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization
por: Ying, Yufan, et al.
Publicado: (2021)

CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo
por: Xu, Xin, et al.
Publicado: (2017)

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila
por: Worpenberg, Lina, et al.
Publicado: (2021)

FTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an m(6)A dependent pathway
por: Shen, Haixiang, et al.
Publicado: (2022)

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding
por: Wang, Wei, et al.
Publicado: (2021)

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N(6)-Methyladenosine-Modified RNAs
por: Micaelli, Mariachiara, et al.
Publicado: (2022)

Author Correction: METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding
por: Wang, Wei, et al.
Publicado: (2021)

N(6)‐methyladenosine‐binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay
por: Xia, Tian‐Liang, et al.
Publicado: (2021)

N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor'LOXL3
por: Shi, Hao‐ze, et al.
Publicado: (2022)

Plant YTHDF proteins are direct effectors of antiviral immunity against an N6 ‐methyladenosine‐containing RNA virus
por: Martínez‐Pérez, Mireya, et al.
Publicado: (2023)

N6-Methyladenosine Reader YTHDF2 Enhances Non-Small-Cell Lung Cancer Cell Proliferation and Metastasis through Mediating circ_SFMBT2 Degradation
por: Xu, Jing, et al.
Publicado: (2022)

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer
por: Wang, Song, et al.
Publicado: (2017)

N(6)-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication
por: Chen, Danyu, et al.
Publicado: (2022)

N(6)-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections
por: Feng, Jian, et al.
Publicado: (2023)

RNAa and Vector-Mediated Overexpression of DIRAS1 Suppresses Tumor Growth and Migration in Renal Cell Carcinoma
por: Xu, Xin, et al.
Publicado: (2018)

The N(6)-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response
por: Zong, Xin, et al.
Publicado: (2021)

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner
por: Yang, Yang, et al.
Publicado: (2023)

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
por: Han, Zhenbo, et al.
Publicado: (2021)

Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3β
por: Li, Hongyan, et al.
Publicado: (2021)

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy
por: Xu, Hongfei, et al.
Publicado: (2021)

YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation
por: Huang, Chen‐Song, et al.
Publicado: (2022)

N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
por: Wang, Qianqing, et al.
Publicado: (2020)

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer
por: Liu, Tong, et al.
Publicado: (2020)

YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA
por: Zhang, Zhaolong, et al.
Publicado: (2020)

METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N(6)‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury
por: Feng, Yang, et al.
Publicado: (2023)

The Regulatory Role of RNA Metabolism Regulator TDP-43 in Human Cancer
por: Ma, Xueyou, et al.
Publicado: (2021)

Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma
por: Bian, Saiyan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_97glc7jv3ce7blnmjcq0bdh49a