Programmed genome rearrangements in ciliates

Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic geno...

Descripción completa

Detalles Bibliográficos
Autores principales: Rzeszutek, Iwona, Maurer-Alcalá, Xyrus X., Nowacki, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599177/
https://www.ncbi.nlm.nih.gov/pubmed/32462406
http://dx.doi.org/10.1007/s00018-020-03555-2
_version_ 1783602815304728576
author Rzeszutek, Iwona
Maurer-Alcalá, Xyrus X.
Nowacki, Mariusz
author_facet Rzeszutek, Iwona
Maurer-Alcalá, Xyrus X.
Nowacki, Mariusz
author_sort Rzeszutek, Iwona
collection PubMed
description Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as DNA amplification. In this review, we discuss the similarities and differences in the genome reorganization processes of the model ciliates Paramecium and Tetrahymena (class Oligohymenophorea), and the distantly related Euplotes, Stylonychia, and Oxytricha (class Spirotrichea).
format Online
Article
Text
id pubmed-7599177
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-75991772020-11-10 Programmed genome rearrangements in ciliates Rzeszutek, Iwona Maurer-Alcalá, Xyrus X. Nowacki, Mariusz Cell Mol Life Sci Review Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as DNA amplification. In this review, we discuss the similarities and differences in the genome reorganization processes of the model ciliates Paramecium and Tetrahymena (class Oligohymenophorea), and the distantly related Euplotes, Stylonychia, and Oxytricha (class Spirotrichea). Springer International Publishing 2020-05-27 2020 /pmc/articles/PMC7599177/ /pubmed/32462406 http://dx.doi.org/10.1007/s00018-020-03555-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Rzeszutek, Iwona
Maurer-Alcalá, Xyrus X.
Nowacki, Mariusz
Programmed genome rearrangements in ciliates
title Programmed genome rearrangements in ciliates
title_full Programmed genome rearrangements in ciliates
title_fullStr Programmed genome rearrangements in ciliates
title_full_unstemmed Programmed genome rearrangements in ciliates
title_short Programmed genome rearrangements in ciliates
title_sort programmed genome rearrangements in ciliates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599177/
https://www.ncbi.nlm.nih.gov/pubmed/32462406
http://dx.doi.org/10.1007/s00018-020-03555-2
work_keys_str_mv AT rzeszutekiwona programmedgenomerearrangementsinciliates
AT maureralcalaxyrusx programmedgenomerearrangementsinciliates
AT nowackimariusz programmedgenomerearrangementsinciliates

Ejemplares similares