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Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival

Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace i...

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Autores principales: Timmins, Iain R., Zaccardi, Francesco, Nelson, Christopher P., Franks, Paul, Yates, Thomas, Dudbridge, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599247/
https://www.ncbi.nlm.nih.gov/pubmed/33128006
http://dx.doi.org/10.1038/s42003-020-01357-7
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author Timmins, Iain R.
Zaccardi, Francesco
Nelson, Christopher P.
Franks, Paul
Yates, Thomas
Dudbridge, Frank
author_facet Timmins, Iain R.
Zaccardi, Francesco
Nelson, Christopher P.
Franks, Paul
Yates, Thomas
Dudbridge, Frank
author_sort Timmins, Iain R.
collection PubMed
description Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P < 5 × 10(−8)), 11 of which are novel. We estimate the SNP-based heritability as 13.2% (s.e. = 0.21%), reducing to 8.9% (s.e. = 0.17%) with adjustment for body mass index. Significant genetic correlations are observed with cardiometabolic, respiratory and psychiatric traits, educational attainment and all-cause mortality. Mendelian randomization analyses suggest a potential causal link of increasing walking pace with a lower cardiometabolic risk profile. Given its low heritability and simple measurement, these findings suggest that self-reported walking pace is a pragmatic target for interventions aiming for general benefits on health.
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spelling pubmed-75992472020-11-02 Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival Timmins, Iain R. Zaccardi, Francesco Nelson, Christopher P. Franks, Paul Yates, Thomas Dudbridge, Frank Commun Biol Article Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P < 5 × 10(−8)), 11 of which are novel. We estimate the SNP-based heritability as 13.2% (s.e. = 0.21%), reducing to 8.9% (s.e. = 0.17%) with adjustment for body mass index. Significant genetic correlations are observed with cardiometabolic, respiratory and psychiatric traits, educational attainment and all-cause mortality. Mendelian randomization analyses suggest a potential causal link of increasing walking pace with a lower cardiometabolic risk profile. Given its low heritability and simple measurement, these findings suggest that self-reported walking pace is a pragmatic target for interventions aiming for general benefits on health. Nature Publishing Group UK 2020-10-30 /pmc/articles/PMC7599247/ /pubmed/33128006 http://dx.doi.org/10.1038/s42003-020-01357-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Timmins, Iain R.
Zaccardi, Francesco
Nelson, Christopher P.
Franks, Paul
Yates, Thomas
Dudbridge, Frank
Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title_full Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title_fullStr Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title_full_unstemmed Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title_short Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
title_sort genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599247/
https://www.ncbi.nlm.nih.gov/pubmed/33128006
http://dx.doi.org/10.1038/s42003-020-01357-7
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