Cargando…

A role of oligodendrocytes in information processing

Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to...

Descripción completa

Detalles Bibliográficos
Autores principales: Moore, Sharlen, Meschkat, Martin, Ruhwedel, Torben, Trevisiol, Andrea, Tzvetanova, Iva D., Battefeld, Arne, Kusch, Kathrin, Kole, Maarten H. P., Strenzke, Nicola, Möbius, Wiebke, de Hoz, Livia, Nave, Klaus-Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599337/
https://www.ncbi.nlm.nih.gov/pubmed/33127910
http://dx.doi.org/10.1038/s41467-020-19152-7
_version_ 1783602847801147392
author Moore, Sharlen
Meschkat, Martin
Ruhwedel, Torben
Trevisiol, Andrea
Tzvetanova, Iva D.
Battefeld, Arne
Kusch, Kathrin
Kole, Maarten H. P.
Strenzke, Nicola
Möbius, Wiebke
de Hoz, Livia
Nave, Klaus-Armin
author_facet Moore, Sharlen
Meschkat, Martin
Ruhwedel, Torben
Trevisiol, Andrea
Tzvetanova, Iva D.
Battefeld, Arne
Kusch, Kathrin
Kole, Maarten H. P.
Strenzke, Nicola
Möbius, Wiebke
de Hoz, Livia
Nave, Klaus-Armin
author_sort Moore, Sharlen
collection PubMed
description Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition to speeding up conduction velocity. Here, we analyze the role of myelin in auditory information processing using paradigms that are also good predictors of speech understanding in humans. We compare mice with different degrees of dysmyelination using acute multiunit recordings in the auditory cortex, in combination with behavioral readouts. We find complex alterations of neuronal responses that reflect fatigue and temporal acuity deficits. We observe partially discriminable but similar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically. We suggest a model in which myelination contributes to sustained stimulus perception in temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical information processing.
format Online
Article
Text
id pubmed-7599337
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-75993372020-11-10 A role of oligodendrocytes in information processing Moore, Sharlen Meschkat, Martin Ruhwedel, Torben Trevisiol, Andrea Tzvetanova, Iva D. Battefeld, Arne Kusch, Kathrin Kole, Maarten H. P. Strenzke, Nicola Möbius, Wiebke de Hoz, Livia Nave, Klaus-Armin Nat Commun Article Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition to speeding up conduction velocity. Here, we analyze the role of myelin in auditory information processing using paradigms that are also good predictors of speech understanding in humans. We compare mice with different degrees of dysmyelination using acute multiunit recordings in the auditory cortex, in combination with behavioral readouts. We find complex alterations of neuronal responses that reflect fatigue and temporal acuity deficits. We observe partially discriminable but similar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically. We suggest a model in which myelination contributes to sustained stimulus perception in temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical information processing. Nature Publishing Group UK 2020-10-30 /pmc/articles/PMC7599337/ /pubmed/33127910 http://dx.doi.org/10.1038/s41467-020-19152-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moore, Sharlen
Meschkat, Martin
Ruhwedel, Torben
Trevisiol, Andrea
Tzvetanova, Iva D.
Battefeld, Arne
Kusch, Kathrin
Kole, Maarten H. P.
Strenzke, Nicola
Möbius, Wiebke
de Hoz, Livia
Nave, Klaus-Armin
A role of oligodendrocytes in information processing
title A role of oligodendrocytes in information processing
title_full A role of oligodendrocytes in information processing
title_fullStr A role of oligodendrocytes in information processing
title_full_unstemmed A role of oligodendrocytes in information processing
title_short A role of oligodendrocytes in information processing
title_sort role of oligodendrocytes in information processing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599337/
https://www.ncbi.nlm.nih.gov/pubmed/33127910
http://dx.doi.org/10.1038/s41467-020-19152-7
work_keys_str_mv AT mooresharlen aroleofoligodendrocytesininformationprocessing
AT meschkatmartin aroleofoligodendrocytesininformationprocessing
AT ruhwedeltorben aroleofoligodendrocytesininformationprocessing
AT trevisiolandrea aroleofoligodendrocytesininformationprocessing
AT tzvetanovaivad aroleofoligodendrocytesininformationprocessing
AT battefeldarne aroleofoligodendrocytesininformationprocessing
AT kuschkathrin aroleofoligodendrocytesininformationprocessing
AT kolemaartenhp aroleofoligodendrocytesininformationprocessing
AT strenzkenicola aroleofoligodendrocytesininformationprocessing
AT mobiuswiebke aroleofoligodendrocytesininformationprocessing
AT dehozlivia aroleofoligodendrocytesininformationprocessing
AT naveklausarmin aroleofoligodendrocytesininformationprocessing
AT mooresharlen roleofoligodendrocytesininformationprocessing
AT meschkatmartin roleofoligodendrocytesininformationprocessing
AT ruhwedeltorben roleofoligodendrocytesininformationprocessing
AT trevisiolandrea roleofoligodendrocytesininformationprocessing
AT tzvetanovaivad roleofoligodendrocytesininformationprocessing
AT battefeldarne roleofoligodendrocytesininformationprocessing
AT kuschkathrin roleofoligodendrocytesininformationprocessing
AT kolemaartenhp roleofoligodendrocytesininformationprocessing
AT strenzkenicola roleofoligodendrocytesininformationprocessing
AT mobiuswiebke roleofoligodendrocytesininformationprocessing
AT dehozlivia roleofoligodendrocytesininformationprocessing
AT naveklausarmin roleofoligodendrocytesininformationprocessing