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Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis

BACKGROUND: Cardiovascular disease is a common comorbidity of patients with nonalcoholic fatty liver disease (NAFLD), particularly coronary artery disease and congestive heart failure. However, the relation between NAFLD and cardiac conduction defects has not been well studied. This systematic revie...

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Autores principales: Wijarnpreecha, Karn, Panjawatanan, Panadeekarn, Kroner, Paul T., Cheungpasitporn, Wisit, Ungprasert, Patompong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599342/
https://www.ncbi.nlm.nih.gov/pubmed/33162743
http://dx.doi.org/10.20524/aog.2020.0535
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author Wijarnpreecha, Karn
Panjawatanan, Panadeekarn
Kroner, Paul T.
Cheungpasitporn, Wisit
Ungprasert, Patompong
author_facet Wijarnpreecha, Karn
Panjawatanan, Panadeekarn
Kroner, Paul T.
Cheungpasitporn, Wisit
Ungprasert, Patompong
author_sort Wijarnpreecha, Karn
collection PubMed
description BACKGROUND: Cardiovascular disease is a common comorbidity of patients with nonalcoholic fatty liver disease (NAFLD), particularly coronary artery disease and congestive heart failure. However, the relation between NAFLD and cardiac conduction defects has not been well studied. This systematic review and meta-analysis was conducted to identify all available studies on this association and summarize their results. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through June 2020 to identify studies that compared the risk of a cardiac conduction defect among patients with NAFLD versus those without. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Three cross-sectional studies with 3651 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of a cardiac conduction defect was significantly higher among patients with NAFLD than in those without NAFLD, with a pooled odds ratio of 5.17 (95% confidence interval 1.34-20.01; I(2) 96%). CONCLUSION: A significantly greater risk of cardiac conduction defects among patients with NAFLD was observed in this meta-analysis. How this risk should be managed in clinical practice requires further investigation.
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spelling pubmed-75993422020-11-05 Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis Wijarnpreecha, Karn Panjawatanan, Panadeekarn Kroner, Paul T. Cheungpasitporn, Wisit Ungprasert, Patompong Ann Gastroenterol Original Article BACKGROUND: Cardiovascular disease is a common comorbidity of patients with nonalcoholic fatty liver disease (NAFLD), particularly coronary artery disease and congestive heart failure. However, the relation between NAFLD and cardiac conduction defects has not been well studied. This systematic review and meta-analysis was conducted to identify all available studies on this association and summarize their results. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through June 2020 to identify studies that compared the risk of a cardiac conduction defect among patients with NAFLD versus those without. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Three cross-sectional studies with 3651 participants fulfilled the eligibility criteria and were included in this meta-analysis. The risk of a cardiac conduction defect was significantly higher among patients with NAFLD than in those without NAFLD, with a pooled odds ratio of 5.17 (95% confidence interval 1.34-20.01; I(2) 96%). CONCLUSION: A significantly greater risk of cardiac conduction defects among patients with NAFLD was observed in this meta-analysis. How this risk should be managed in clinical practice requires further investigation. Hellenic Society of Gastroenterology 2020 2020-09-16 /pmc/articles/PMC7599342/ /pubmed/33162743 http://dx.doi.org/10.20524/aog.2020.0535 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wijarnpreecha, Karn
Panjawatanan, Panadeekarn
Kroner, Paul T.
Cheungpasitporn, Wisit
Ungprasert, Patompong
Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title_full Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title_fullStr Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title_full_unstemmed Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title_short Association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
title_sort association between cardiac conduction defect and nonalcoholic fatty liver disease: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599342/
https://www.ncbi.nlm.nih.gov/pubmed/33162743
http://dx.doi.org/10.20524/aog.2020.0535
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