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Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on gly...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599450/ https://www.ncbi.nlm.nih.gov/pubmed/33053624 http://dx.doi.org/10.3390/nano10102005 |
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author | Virgen-Ortiz, Adolfo Apolinar-Iribe, Alejandro Díaz-Reval, Irene Parra-Delgado, Hortensia Limón-Miranda, Saraí Sánchez-Pastor, Enrique Alejandro Castro-Sánchez, Luis Jesús Castillo, Santos Dagnino-Acosta, Adan Bonales-Alatorre, Edgar Rodríguez-Hernández, Alejandrina |
author_facet | Virgen-Ortiz, Adolfo Apolinar-Iribe, Alejandro Díaz-Reval, Irene Parra-Delgado, Hortensia Limón-Miranda, Saraí Sánchez-Pastor, Enrique Alejandro Castro-Sánchez, Luis Jesús Castillo, Santos Dagnino-Acosta, Adan Bonales-Alatorre, Edgar Rodríguez-Hernández, Alejandrina |
author_sort | Virgen-Ortiz, Adolfo |
collection | PubMed |
description | Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches. |
format | Online Article Text |
id | pubmed-7599450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75994502020-11-01 Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats Virgen-Ortiz, Adolfo Apolinar-Iribe, Alejandro Díaz-Reval, Irene Parra-Delgado, Hortensia Limón-Miranda, Saraí Sánchez-Pastor, Enrique Alejandro Castro-Sánchez, Luis Jesús Castillo, Santos Dagnino-Acosta, Adan Bonales-Alatorre, Edgar Rodríguez-Hernández, Alejandrina Nanomaterials (Basel) Communication Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches. MDPI 2020-10-12 /pmc/articles/PMC7599450/ /pubmed/33053624 http://dx.doi.org/10.3390/nano10102005 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Virgen-Ortiz, Adolfo Apolinar-Iribe, Alejandro Díaz-Reval, Irene Parra-Delgado, Hortensia Limón-Miranda, Saraí Sánchez-Pastor, Enrique Alejandro Castro-Sánchez, Luis Jesús Castillo, Santos Dagnino-Acosta, Adan Bonales-Alatorre, Edgar Rodríguez-Hernández, Alejandrina Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title | Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title_full | Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title_fullStr | Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title_full_unstemmed | Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title_short | Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats |
title_sort | zinc oxide nanoparticles induce an adverse effect on blood glucose levels depending on the dose and route of administration in healthy and diabetic rats |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599450/ https://www.ncbi.nlm.nih.gov/pubmed/33053624 http://dx.doi.org/10.3390/nano10102005 |
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