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Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on gly...

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Autores principales: Virgen-Ortiz, Adolfo, Apolinar-Iribe, Alejandro, Díaz-Reval, Irene, Parra-Delgado, Hortensia, Limón-Miranda, Saraí, Sánchez-Pastor, Enrique Alejandro, Castro-Sánchez, Luis, Jesús Castillo, Santos, Dagnino-Acosta, Adan, Bonales-Alatorre, Edgar, Rodríguez-Hernández, Alejandrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599450/
https://www.ncbi.nlm.nih.gov/pubmed/33053624
http://dx.doi.org/10.3390/nano10102005
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author Virgen-Ortiz, Adolfo
Apolinar-Iribe, Alejandro
Díaz-Reval, Irene
Parra-Delgado, Hortensia
Limón-Miranda, Saraí
Sánchez-Pastor, Enrique Alejandro
Castro-Sánchez, Luis
Jesús Castillo, Santos
Dagnino-Acosta, Adan
Bonales-Alatorre, Edgar
Rodríguez-Hernández, Alejandrina
author_facet Virgen-Ortiz, Adolfo
Apolinar-Iribe, Alejandro
Díaz-Reval, Irene
Parra-Delgado, Hortensia
Limón-Miranda, Saraí
Sánchez-Pastor, Enrique Alejandro
Castro-Sánchez, Luis
Jesús Castillo, Santos
Dagnino-Acosta, Adan
Bonales-Alatorre, Edgar
Rodríguez-Hernández, Alejandrina
author_sort Virgen-Ortiz, Adolfo
collection PubMed
description Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches.
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spelling pubmed-75994502020-11-01 Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats Virgen-Ortiz, Adolfo Apolinar-Iribe, Alejandro Díaz-Reval, Irene Parra-Delgado, Hortensia Limón-Miranda, Saraí Sánchez-Pastor, Enrique Alejandro Castro-Sánchez, Luis Jesús Castillo, Santos Dagnino-Acosta, Adan Bonales-Alatorre, Edgar Rodríguez-Hernández, Alejandrina Nanomaterials (Basel) Communication Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches. MDPI 2020-10-12 /pmc/articles/PMC7599450/ /pubmed/33053624 http://dx.doi.org/10.3390/nano10102005 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Virgen-Ortiz, Adolfo
Apolinar-Iribe, Alejandro
Díaz-Reval, Irene
Parra-Delgado, Hortensia
Limón-Miranda, Saraí
Sánchez-Pastor, Enrique Alejandro
Castro-Sánchez, Luis
Jesús Castillo, Santos
Dagnino-Acosta, Adan
Bonales-Alatorre, Edgar
Rodríguez-Hernández, Alejandrina
Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title_full Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title_fullStr Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title_full_unstemmed Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title_short Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats
title_sort zinc oxide nanoparticles induce an adverse effect on blood glucose levels depending on the dose and route of administration in healthy and diabetic rats
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599450/
https://www.ncbi.nlm.nih.gov/pubmed/33053624
http://dx.doi.org/10.3390/nano10102005
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