Cargando…

Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study

Background: Marfan’s syndrome (MFS) seems to be frequently associated with colonic diverticulosis, but the prevalence of diverticula and symptoms evocative of diverticular disease in this population are still unknown. Methods: This prospective case control study included 90 consecutive patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Maconi, Giovanni, Pini, Alessandro, Pasqualone, Elia, Ardizzone, Sandro, Bassotti, Gabrio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599469/
https://www.ncbi.nlm.nih.gov/pubmed/32998474
http://dx.doi.org/10.3390/jcm9103141
_version_ 1783602882197585920
author Maconi, Giovanni
Pini, Alessandro
Pasqualone, Elia
Ardizzone, Sandro
Bassotti, Gabrio
author_facet Maconi, Giovanni
Pini, Alessandro
Pasqualone, Elia
Ardizzone, Sandro
Bassotti, Gabrio
author_sort Maconi, Giovanni
collection PubMed
description Background: Marfan’s syndrome (MFS) seems to be frequently associated with colonic diverticulosis, but the prevalence of diverticula and symptoms evocative of diverticular disease in this population are still unknown. Methods: This prospective case control study included 90 consecutive patients with MFS, 90 unselected controls, and 90 asymptomatic subjects. The clinical characteristics, including lower gastrointestinal symptoms, and ultrasonographic features of the bowel, including diverticula and thickening of the muscularis propria of the sigmoid colon, were investigated. In addition, the genotype of MFS patients was assessed. The characteristics of patients and controls were compared using parametric tests. Results: Complaints of abdominal symptoms were made by 23 (25.6%) patients with MFS and 48 (53%) control subjects (p < 0.01). Constipation and bloating were reported less frequently by MFS patients than controls (constipation: 13.3% vs. 26.6%, p = 0.039; bloating: 3.3% vs. 41.1%, p < 0.0001), while other symptoms were not significantly different. Sigmoid diverticulosis was detected in 12 (12.3%) patients with MFS, as well as in 3 (3.3%) asymptomatic healthy subjects and 4 (4.4%) random controls (p = 0.0310). The genetic variants of MFS were not correlated with symptoms or diverticula. Conclusion: Patients with MFS have a greater prevalence of diverticula, although less abdominal symptoms, compared to the general population. Symptoms and diverticula in MFS are not correlated with any genetic variant.
format Online
Article
Text
id pubmed-7599469
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75994692020-11-01 Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study Maconi, Giovanni Pini, Alessandro Pasqualone, Elia Ardizzone, Sandro Bassotti, Gabrio J Clin Med Article Background: Marfan’s syndrome (MFS) seems to be frequently associated with colonic diverticulosis, but the prevalence of diverticula and symptoms evocative of diverticular disease in this population are still unknown. Methods: This prospective case control study included 90 consecutive patients with MFS, 90 unselected controls, and 90 asymptomatic subjects. The clinical characteristics, including lower gastrointestinal symptoms, and ultrasonographic features of the bowel, including diverticula and thickening of the muscularis propria of the sigmoid colon, were investigated. In addition, the genotype of MFS patients was assessed. The characteristics of patients and controls were compared using parametric tests. Results: Complaints of abdominal symptoms were made by 23 (25.6%) patients with MFS and 48 (53%) control subjects (p < 0.01). Constipation and bloating were reported less frequently by MFS patients than controls (constipation: 13.3% vs. 26.6%, p = 0.039; bloating: 3.3% vs. 41.1%, p < 0.0001), while other symptoms were not significantly different. Sigmoid diverticulosis was detected in 12 (12.3%) patients with MFS, as well as in 3 (3.3%) asymptomatic healthy subjects and 4 (4.4%) random controls (p = 0.0310). The genetic variants of MFS were not correlated with symptoms or diverticula. Conclusion: Patients with MFS have a greater prevalence of diverticula, although less abdominal symptoms, compared to the general population. Symptoms and diverticula in MFS are not correlated with any genetic variant. MDPI 2020-09-28 /pmc/articles/PMC7599469/ /pubmed/32998474 http://dx.doi.org/10.3390/jcm9103141 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maconi, Giovanni
Pini, Alessandro
Pasqualone, Elia
Ardizzone, Sandro
Bassotti, Gabrio
Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title_full Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title_fullStr Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title_full_unstemmed Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title_short Abdominal Symptoms and Colonic Diverticula in Marfan’s Syndrome: A Clinical and Ultrasonographic Case Control Study
title_sort abdominal symptoms and colonic diverticula in marfan’s syndrome: a clinical and ultrasonographic case control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599469/
https://www.ncbi.nlm.nih.gov/pubmed/32998474
http://dx.doi.org/10.3390/jcm9103141
work_keys_str_mv AT maconigiovanni abdominalsymptomsandcolonicdiverticulainmarfanssyndromeaclinicalandultrasonographiccasecontrolstudy
AT pinialessandro abdominalsymptomsandcolonicdiverticulainmarfanssyndromeaclinicalandultrasonographiccasecontrolstudy
AT pasqualoneelia abdominalsymptomsandcolonicdiverticulainmarfanssyndromeaclinicalandultrasonographiccasecontrolstudy
AT ardizzonesandro abdominalsymptomsandcolonicdiverticulainmarfanssyndromeaclinicalandultrasonographiccasecontrolstudy
AT bassottigabrio abdominalsymptomsandcolonicdiverticulainmarfanssyndromeaclinicalandultrasonographiccasecontrolstudy