Cargando…

Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse

A 10-year-old horse presented with two 3-cm diameter exophytic masses over the fetlock. Histology was consistent with a hyperplastic squamous papilloma and numerous cell changes consistent with papillomavirus (PV) infection were visible. Partial sequences of PV L1 and E1 ORFs were amplified using co...

Descripción completa

Detalles Bibliográficos
Autores principales: Munday, John S., Hardcastle, Michael R., Sim, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599537/
https://www.ncbi.nlm.nih.gov/pubmed/33027924
http://dx.doi.org/10.3390/pathogens9100816
_version_ 1783602899376406528
author Munday, John S.
Hardcastle, Michael R.
Sim, Melissa
author_facet Munday, John S.
Hardcastle, Michael R.
Sim, Melissa
author_sort Munday, John S.
collection PubMed
description A 10-year-old horse presented with two 3-cm diameter exophytic masses over the fetlock. Histology was consistent with a hyperplastic squamous papilloma and numerous cell changes consistent with papillomavirus (PV) infection were visible. Partial sequences of PV L1 and E1 ORFs were amplified using consensus PCR primers. The sequences were most similar to Equus caballus type 1 (EcPV1). However, as the sequences were only around 73% similar to EcPV1, they appear to be from a novel PV type that is likely to be within the Zetapapillomavirus genus. The papillomas were treated with topical imiquimod and resolved within 14 weeks. The clinical presentation of the papillomas in the present case had marked differences to the clinical presentation of EcPV-1-induced papillomas, which are typically small, numerous and around the face. Observations from the present case increase the clinical spectrum of PV-induced lesions in this species as well as providing evidence of an additional novel papillomavirus that is able to cause disease in horses.
format Online
Article
Text
id pubmed-7599537
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75995372020-11-01 Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse Munday, John S. Hardcastle, Michael R. Sim, Melissa Pathogens Case Report A 10-year-old horse presented with two 3-cm diameter exophytic masses over the fetlock. Histology was consistent with a hyperplastic squamous papilloma and numerous cell changes consistent with papillomavirus (PV) infection were visible. Partial sequences of PV L1 and E1 ORFs were amplified using consensus PCR primers. The sequences were most similar to Equus caballus type 1 (EcPV1). However, as the sequences were only around 73% similar to EcPV1, they appear to be from a novel PV type that is likely to be within the Zetapapillomavirus genus. The papillomas were treated with topical imiquimod and resolved within 14 weeks. The clinical presentation of the papillomas in the present case had marked differences to the clinical presentation of EcPV-1-induced papillomas, which are typically small, numerous and around the face. Observations from the present case increase the clinical spectrum of PV-induced lesions in this species as well as providing evidence of an additional novel papillomavirus that is able to cause disease in horses. MDPI 2020-10-05 /pmc/articles/PMC7599537/ /pubmed/33027924 http://dx.doi.org/10.3390/pathogens9100816 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Munday, John S.
Hardcastle, Michael R.
Sim, Melissa
Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title_full Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title_fullStr Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title_full_unstemmed Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title_short Detection of a Putative Novel Papillomavirus Type within a Large Exophytic Papilloma on the Fetlock of a Horse
title_sort detection of a putative novel papillomavirus type within a large exophytic papilloma on the fetlock of a horse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599537/
https://www.ncbi.nlm.nih.gov/pubmed/33027924
http://dx.doi.org/10.3390/pathogens9100816
work_keys_str_mv AT mundayjohns detectionofaputativenovelpapillomavirustypewithinalargeexophyticpapillomaonthefetlockofahorse
AT hardcastlemichaelr detectionofaputativenovelpapillomavirustypewithinalargeexophyticpapillomaonthefetlockofahorse
AT simmelissa detectionofaputativenovelpapillomavirustypewithinalargeexophyticpapillomaonthefetlockofahorse