Construction of Stable Reporter Flaviviruses and Their Applications

Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed. Reporter viruses represent potent tools to fill this gap but have been hindered by genetic ins...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Coleman, Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599567/
https://www.ncbi.nlm.nih.gov/pubmed/32992987
http://dx.doi.org/10.3390/v12101082
_version_ 1783602906956562432
author Baker, Coleman
Shi, Pei-Yong
author_facet Baker, Coleman
Shi, Pei-Yong
author_sort Baker, Coleman
collection PubMed
description Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed. Reporter viruses represent potent tools to fill this gap but have been hindered by genetic instability. Recent advances have overcome these hurdles, opening the way for increased use of stable reporter flaviviruses to diagnose infections, screen and study antiviral compounds, and serve as potential vaccine vectors.
format Online
Article
Text
id pubmed-7599567
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75995672020-11-01 Construction of Stable Reporter Flaviviruses and Their Applications Baker, Coleman Shi, Pei-Yong Viruses Review Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed. Reporter viruses represent potent tools to fill this gap but have been hindered by genetic instability. Recent advances have overcome these hurdles, opening the way for increased use of stable reporter flaviviruses to diagnose infections, screen and study antiviral compounds, and serve as potential vaccine vectors. MDPI 2020-09-25 /pmc/articles/PMC7599567/ /pubmed/32992987 http://dx.doi.org/10.3390/v12101082 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baker, Coleman
Shi, Pei-Yong
Construction of Stable Reporter Flaviviruses and Their Applications
title Construction of Stable Reporter Flaviviruses and Their Applications
title_full Construction of Stable Reporter Flaviviruses and Their Applications
title_fullStr Construction of Stable Reporter Flaviviruses and Their Applications
title_full_unstemmed Construction of Stable Reporter Flaviviruses and Their Applications
title_short Construction of Stable Reporter Flaviviruses and Their Applications
title_sort construction of stable reporter flaviviruses and their applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599567/
https://www.ncbi.nlm.nih.gov/pubmed/32992987
http://dx.doi.org/10.3390/v12101082
work_keys_str_mv AT bakercoleman constructionofstablereporterflavivirusesandtheirapplications
AT shipeiyong constructionofstablereporterflavivirusesandtheirapplications

Ejemplares similares