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Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis

Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) case...

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Autores principales: Wimalasiri-Yapa, B.M.C.R., Yapa, Harith E., Huang, Xiaodong, Hafner, Louise M., Kenna, Tony J., Frentiu, Francesca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599580/
https://www.ncbi.nlm.nih.gov/pubmed/33036370
http://dx.doi.org/10.3390/v12101137
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author Wimalasiri-Yapa, B.M.C.R.
Yapa, Harith E.
Huang, Xiaodong
Hafner, Louise M.
Kenna, Tony J.
Frentiu, Francesca D.
author_facet Wimalasiri-Yapa, B.M.C.R.
Yapa, Harith E.
Huang, Xiaodong
Hafner, Louise M.
Kenna, Tony J.
Frentiu, Francesca D.
author_sort Wimalasiri-Yapa, B.M.C.R.
collection PubMed
description Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well characterized. Articles were extracted from PubMed and Scopus databases reporting original data from patients with arthralgia/arthritis, according to the Cochrane Collaboration. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 137 articles reporting ZIKV-associated joint symptoms were reviewed. Arthralgia was more frequently reported (n = 124 from case studies, n = 1779 from population-based studies) than arthritis (n = 7 and n = 121, respectively). Arthralgia was resolved in <1 week in 54%, and within 1–2 weeks in 40% of cases. The meta-analysis of cases in population-based studies identified a pooled prevalence of 53.55% for arthralgia. The pooled prevalence of arthralgia/arthritis during outbreaks depended on the geographic location, with a higher joint symptom burden observed in the Americas compared to South East Asia (Brazil: 60.79%; Puerto Rico: 68.89% and South East Asia: 26.46%). We conclude that non-specific constitutional arthralgia is the most common joint manifestation during ZIKV infection, being present in nearly half of cases but resolving by two weeks in >90% of these. We found no evidence of chronic rheumatic manifestations following ZIKV infection.
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spelling pubmed-75995802020-11-01 Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis Wimalasiri-Yapa, B.M.C.R. Yapa, Harith E. Huang, Xiaodong Hafner, Louise M. Kenna, Tony J. Frentiu, Francesca D. Viruses Article Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well characterized. Articles were extracted from PubMed and Scopus databases reporting original data from patients with arthralgia/arthritis, according to the Cochrane Collaboration. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 137 articles reporting ZIKV-associated joint symptoms were reviewed. Arthralgia was more frequently reported (n = 124 from case studies, n = 1779 from population-based studies) than arthritis (n = 7 and n = 121, respectively). Arthralgia was resolved in <1 week in 54%, and within 1–2 weeks in 40% of cases. The meta-analysis of cases in population-based studies identified a pooled prevalence of 53.55% for arthralgia. The pooled prevalence of arthralgia/arthritis during outbreaks depended on the geographic location, with a higher joint symptom burden observed in the Americas compared to South East Asia (Brazil: 60.79%; Puerto Rico: 68.89% and South East Asia: 26.46%). We conclude that non-specific constitutional arthralgia is the most common joint manifestation during ZIKV infection, being present in nearly half of cases but resolving by two weeks in >90% of these. We found no evidence of chronic rheumatic manifestations following ZIKV infection. MDPI 2020-10-07 /pmc/articles/PMC7599580/ /pubmed/33036370 http://dx.doi.org/10.3390/v12101137 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wimalasiri-Yapa, B.M.C.R.
Yapa, Harith E.
Huang, Xiaodong
Hafner, Louise M.
Kenna, Tony J.
Frentiu, Francesca D.
Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title_full Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title_fullStr Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title_full_unstemmed Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title_short Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
title_sort zika virus and arthritis/arthralgia: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599580/
https://www.ncbi.nlm.nih.gov/pubmed/33036370
http://dx.doi.org/10.3390/v12101137
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